Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China.
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China.
Pregnancy Hypertens. 2020 Apr;20:111-118. doi: 10.1016/j.preghy.2020.03.009. Epub 2020 Mar 24.
The predictive role of neutrophil-to-lymphocyte ratio (NLR) for preeclampsia (PE) has been explored in several studies and current evidence seems to be conflicting. The aim of this study is to compare the NLR values of mild and severe preeclampsia with the normotensive pregnant women, in order to explore the predictive role of NLR for preeclampsia and whether the NLR value has significant difference between severe and mild preeclampsia.
We systematically searched Pubmed, Embase, Web of Science and Cochrane database for relative literature up to May 2019. The statistical analysis was performed using Stata 12.0 software.
Totally 15 eligible studies consisting of 3982 patients were enrolled in our meta-analysis. The NLR value is higher in preeclampsia when compared to healthy pregnant women (3270 women, MD: 1.44, 95% CI [1.04, 1.83]). Furthermore, NLR value is higher in severe preeclampsia than in mild preeclampsia (1287 women, MD: 1.12, 95% CI [0.69,1.56]).
The findings of our meta-analysis suggest that NLR value is higher in preeclampsia patients especially in severe preeclampsia. The NLR might be a useful laboratory marker for clinical prediction and disease severity evaluation of preeclampsia. However, given that the available evidence is mainly drawn from case-control studies, future cohorts are needed in this field to accurately determine optimal timing and cut-off values that may be used in the clinical setting.
中性粒细胞与淋巴细胞比值（NLR）对先兆子痫（PE）的预测作用已在多项研究中进行了探讨，目前的证据似乎存在矛盾。本研究旨在比较轻度和重度先兆子痫与正常孕妇的 NLR 值，以探讨 NLR 对先兆子痫的预测作用，以及 NLR 值在重度和轻度先兆子痫之间是否存在显著差异。
我们系统地检索了 Pubmed、Embase、Web of Science 和 Cochrane 数据库，以获取截至 2019 年 5 月的相关文献。使用 Stata 12.0 软件进行统计分析。
共有 15 项符合纳入标准的研究，包括 3982 名患者，纳入本 meta 分析。与健康孕妇相比，先兆子痫患者的 NLR 值更高（3270 名女性，MD：1.44，95%CI [1.04,1.83]）。此外，重度先兆子痫患者的 NLR 值高于轻度先兆子痫患者（1287 名女性，MD：1.12，95%CI [0.69,1.56]）。
本 meta 分析的结果表明，NLR 值在先兆子痫患者中较高，尤其是在重度先兆子痫患者中更高。NLR 可能是先兆子痫临床预测和疾病严重程度评估的有用实验室标志物。然而，由于现有证据主要来自病例对照研究，因此需要在该领域进行未来的队列研究，以准确确定可能在临床环境中使用的最佳时机和截断值。
