Trakul Nicholas, Koong Albert C, Chang Daniel T
Department of Radiation Oncology, Keck School of Medicine of University of Southern California, Los Angeles, CA.
Department of Radiation Oncology, Stanford University School of Medicine and Cancer Center, Stanford, CA.
Semin Radiat Oncol. 2014 Apr;24(2):140-7. doi: 10.1016/j.semradonc.2013.11.008.
Most patients diagnosed with pancreatic cancer are unable to have a curative surgical resection. Chemoradiation is a standard of care treatment for patients with locally advanced unresectable disease, but local failure rates are high with conventionally fractionated radiotherapy. However, stereotactic body radiotherapy (SBRT) or stereotactic ablative radiotherapy offers an alternative type of radiation therapy, which allows for the delivery of high-dose, conformal radiation. The high doses and shorter overall treatment time with SBRT may provide advantages in local control, disease outcomes, quality of life, and cost-effectiveness, and further investigation is currently underway. Here, we review the technology behind SBRT for pancreatic malignancy and its future direction in the overall management of pancreatic cancer.
大多数被诊断为胰腺癌的患者无法进行根治性手术切除。放化疗是局部晚期不可切除疾病患者的标准治疗方法，但传统分割放疗的局部失败率很高。然而，立体定向体部放疗（SBRT）或立体定向消融放疗提供了另一种放疗方式，它能够进行高剂量适形放疗。SBRT的高剂量和较短的总治疗时间可能在局部控制、疾病转归、生活质量和成本效益方面具有优势，目前正在进行进一步研究。在此，我们综述了胰腺癌SBRT背后的技术及其在胰腺癌整体治疗中的未来方向。
