Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris Cedex 15, France; CEA, Division of Immuno-Virology, iMETI/DSV, 18 Route du Panorama, 92265 Fontenay-aux-Roses, France.
Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris Cedex 15, France.
Virology. 2014 Apr;454-455:340-52. doi: 10.1016/j.virol.2014.02.021. Epub 2014 Mar 11.
Thirty years after the identification of HIV, a cure for HIV infection is still to be achieved. Advances of combined antiretroviral therapy (cART) in recent years have transformed HIV infection into a chronic disease when treatment is available. However, in spite of the favorable outcomes provided by the newer therapies, cART is not curative and patients are at risk of developing HIV-associated disorders. Moreover, universal access to antiretroviral treatment is restricted by financial obstacles. This review discusses the most recent strategies that have been developed in the search for an HIV cure and to improve life quality of people living with HIV.
三十年来，尽管人们一直在努力寻找治疗方法，但艾滋病病毒（HIV）的治愈方法仍未被发现。近年来，联合抗逆转录病毒疗法（cART）的进展将 HIV 感染转化为一种慢性疾病，只要有治疗方法，就能得到控制。然而，尽管新疗法带来了良好的效果，但 cART 并不能治愈 HIV 感染，患者仍有发生与 HIV 相关疾病的风险。此外，抗逆转录病毒治疗的普及受到了财政障碍的限制。本文综述了目前在寻找 HIV 治愈方法和提高 HIV 感染者生活质量方面的最新进展。
