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尿肠脂肪酸结合蛋白预测坏死性小肠结肠炎。

Urinary intestinal fatty acid binding protein predicts necrotizing enterocolitis.

机构信息

W.F. Connell School of Nursing, Boston College, Chestnut Hill, MA; Department of Nursing, Brigham and Women's Hospital, Boston, MA; Department of Newborn Medicine, Brigham and Women's Hospital, Boston, MA.

Division of Newborn Medicine, Boston Children's Hospital, Boston, MA.

出版信息

J Pediatr. 2014 Jun;164(6):1486-8. doi: 10.1016/j.jpeds.2014.01.057. Epub 2014 Mar 15.

DOI:10.1016/j.jpeds.2014.01.057
PMID:24636854
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4120986/
Abstract

Necrotizing enterocolitis, characterized by sudden onset and rapid progression, remains the most significant gastrointestinal disorder among premature infants. In seeking a predictive biomarker, we found intestinal fatty acid binding protein, an indicator of enterocyte damage, was substantially increased within three and seven days before the diagnosis of necrotizing enterocolitis.

摘要

坏死性小肠结肠炎以突然发作和迅速进展为特征，是早产儿最严重的胃肠道疾病。在寻找预测生物标志物时，我们发现肠脂肪酸结合蛋白（一种肠细胞损伤的指标）在坏死性小肠结肠炎诊断前 3 天至 7 天内显著增加。

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Intestinal microbial profiles in extremely preterm infants with and without necrotizing enterocolitis.极早产儿有无坏死性小肠结肠炎的肠道微生物特征。
Acta Paediatr. 2013 Feb;102(2):129-36. doi: 10.1111/apa.12059. Epub 2012 Nov 21.
2
Noninvasive measurement of fecal calprotectin and serum amyloid A combined with intestinal fatty acid-binding protein in necrotizing enterocolitis.采用非侵入性方法检测粪便钙卫蛋白、血清淀粉样蛋白 A 和肠脂肪酸结合蛋白在坏死性小肠结肠炎中的应用。
J Pediatr Surg. 2012 Sep;47(9):1640-5. doi: 10.1016/j.jpedsurg.2012.02.027.
3
Fecal microbiota in premature infants prior to necrotizing enterocolitis.
坏死性小肠结肠炎早期诊断的新兴预测方法。
Front Med (Lausanne). 2022 Sep 16;9:985219. doi: 10.3389/fmed.2022.985219. eCollection 2022.
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Intestinal Inflammation is Significantly Associated With Length Faltering in Preterm Infants at Neonatal Intensive Care Unit Discharge.肠内炎症与新生儿重症监护病房出院时早产儿生长迟滞显著相关。
J Pediatr Gastroenterol Nutr. 2022 Jun 1;74(6):837-844. doi: 10.1097/MPG.0000000000003455. Epub 2022 Apr 26.
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Potential Role of Serum Intestinal Fatty Acid-Binding Protein as a Marker for Early Prediction and Diagnosis of Necrotizing Enterocolitis in Preterm Neonates.血清肠脂肪酸结合蛋白作为早产儿坏死性小肠结肠炎早期预测和诊断标志物的潜在作用
J Indian Assoc Pediatr Surg. 2021 Nov-Dec;26(6):393-400. doi: 10.4103/jiaps.JIAPS_218_20. Epub 2021 Nov 12.
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