18三体妊娠孕妇血清中的甲胎蛋白
[Alpha fetoprotein in maternal serum in pregnancies with trisomy 18].
作者信息
Dix U, Gams M, Grubisic A, Dericks-Tan J S, Langenbeck U
机构信息
Institut für Humangenetik, Klinikum der J.W. Goethe-Universität, Frankfurt.
出版信息
Z Geburtshilfe Perinatol. 1988 Sep-Oct;192(5):231-3.
PMID:2463716
Abstract
Maternal serum alpha-fetoprotein (MS-AFP) was assayed before amniocentesis in 2441 pregnancies of women age 35 or over and of women with prior birth of a child with a chromosome anomaly. Ten cases of trisomy 18 and 25 cases of trisomy 21 were detected. In trisomy 18 without neural tube defect we found MS-AFP levels significantly lower than in trisomy 21.
摘要
在对2441例年龄35岁及以上的孕妇以及之前生育过染色体异常患儿的孕妇进行羊膜穿刺术前，检测了母血清甲胎蛋白（MS-AFP）。检测出10例18三体综合征和25例21三体综合征。在无神经管缺陷的18三体综合征中，我们发现MS-AFP水平显著低于21三体综合征。
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