1Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, AUSTRALIA; 2School of Public Health and Preventive Medicine, Monash University, Melbourne, AUSTRALIA; 3Department of Physiology, Monash University, Melbourne, AUSTRALIA; 4School of Population Health, University of Queensland, Brisbane, AUSTRALIA; 5School of Population and Global Health, Melbourne University, Melbourne, AUSTRALIA; 6School of Sport Science, Exercise and Health, University of Western Australia, Perth, AUSTRALIA; and 7School of Exercise and Nutrition Sciences, Deakin University, Melbourne, AUSTRALIA.
Med Sci Sports Exerc. 2014 Nov;46(11):2053-61. doi: 10.1249/MSS.0000000000000337.
This study aimed to examine whether reductions in sitting time through alternating 30-min bouts of sitting and standing can reduce postprandial glucose, insulin, and triglyceride responses.
Twenty-three overweight/obese sedentary office workers (17 males and six females; mean ± SD: age, 48.2 ± 7.9 yr; body mass index, 29.6 ± 4.0 kg · m(-2)) undertook two short-term (5 d) experimental conditions in an equal, randomized (1:1) order. In a simulated office environment, participants performed typical occupational tasks for 8 h · d(-1) while in a 1) seated work posture (control condition) or 2) interchanging between a seated and standing work posture every 30 min using an electric, height-adjustable workstation (intervention condition). Fasting and postprandial blood samples after a mixed test drink were collected hourly for 4 h on days 1 and 5 of each condition to assess serum insulin, plasma glucose, and triglycerides. Dietary intake (kJ · d(-1)) and physical activity were standardized during each condition. The trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12611000632998).
After adjustment for time (days 1 and 5), incremental area under the analyte time curve differed significantly between conditions for plasma glucose (P = 0.007) but not for serum insulin or plasma triglycerides. Adjusted mean glucose incremental area under the analyte time curve was lowered by 11.1% after the intervention condition (6.38 mM · h(-1) (confidence interval, 5.04-7.71)) relative to the control condition (7.18 mM · h(-1) (confidence interval, 5.85-8.52)). No temporal changes (days 1 vs 5) between conditions were observed.
Alternating standing and sitting in 30-min bouts results in modest beneficial effects on postprandial glucose responses in overweight/obese office workers.
本研究旨在探讨通过交替 30 分钟的坐站活动是否可以减少餐后血糖、胰岛素和甘油三酯的反应来减少久坐时间。
23 名超重/肥胖的久坐办公人员（17 名男性和 6 名女性；平均 ± 标准差：年龄 48.2 ± 7.9 岁；体重指数 29.6 ± 4.0 kg·m(-2)) 以相等的、随机（1:1）顺序进行两项短期（5 天）实验条件。在模拟的办公环境中，参与者每天 8 小时执行典型的职业任务，同时 1）保持坐姿（对照条件）或 2）使用电动、可调节高度的工作站每隔 30 分钟在坐姿和站姿之间交替（干预条件）。在每个条件的第 1 天和第 5 天，在混合测试饮料后空腹和餐后采集每小时 1 次的血样 4 小时，以评估血清胰岛素、血浆葡萄糖和甘油三酯。在每个条件下标准化膳食摄入（kJ·d(-1))和体力活动。该试验已在澳大利亚新西兰临床试验注册处（ACTRN12611000632998）注册。
在调整时间（第 1 天和第 5 天）后，条件之间的分析物时间曲线下的增量面积在血浆葡萄糖方面有显著差异（P = 0.007），但在血清胰岛素或血浆甘油三酯方面没有差异。与对照条件（6.38 mM·h(-1)（置信区间，5.04-7.71））相比，干预条件下的分析物时间曲线下的葡萄糖增量平均降低了 11.1%（7.18 mM·h(-1)（置信区间，5.85-8.52））。在条件之间未观察到时间变化（第 1 天与第 5 天）。
每隔 30 分钟站立和坐下会导致超重/肥胖办公人员餐后血糖反应适度有益。
