嗅觉识别测试对帕金森病诊断的低特异性和敏感性。
Low specificity and sensitivity of smell identification testing for the diagnosis of Parkinson's disease.
作者信息
Rodríguez-Violante Mayela, Gonzalez-Latapi Paulina, Camacho-Ordoñez Azyadeh, Martínez-Ramírez Daniel, Morales-Briceño Hugo, Cervantes-Arriaga Amin
机构信息
Movement disorders clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Neurodegenerative clinical research unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
出版信息
Arq Neuropsiquiatr. 2014 Jan;72(1):33-7. doi: 10.1590/0004-282X20130190.
OBJECTIVE
The aim of this study is to determine if the University of Pennsylvania's Smell Identification Test (UPSIT) is an accurate diagnostic tool for olfactory dysfunction in Parkinson's disease (PD).
METHOD
We included 138 non-demented PD subjects and 175 control subjects matched by gender. Smell identification was tested using UPSIT.
RESULTS
The mean number of UPSIT items correctly identified by controls was 27.52 ± 5.88; the mean score for PD subjects was 19.66 ± 6.08 (p=<0.001). UPSIT sensitivity was 79.7% with a specificity of 68.5% using a cut-off score of ≤ 25. The overall accuracy for the diagnosis of PD was of 75.3%.
CONCLUSION
UPSIT accuracy and specificity were lower than what has been previously reported. Our data demonstrates that 17.5% of items of the UPSIT were not well identified by healthy controls. Further research of the identification of a truly cross-cultural test is warranted.
目的
本研究旨在确定宾夕法尼亚大学嗅觉识别测试（UPSIT）是否为帕金森病（PD）嗅觉功能障碍的准确诊断工具。
方法
我们纳入了138名非痴呆的PD患者和175名按性别匹配的对照者。使用UPSIT测试嗅觉识别能力。
结果
对照组正确识别的UPSIT项目平均数量为27.52±5.88；PD患者的平均得分为19.66±6.08（p<0.001）。使用≤25的临界值时，UPSIT的敏感性为79.7%，特异性为68.5%。PD诊断的总体准确率为75.3%。
结论
UPSIT的准确性和特异性低于先前报道。我们的数据表明，健康对照者不能很好地识别UPSIT中17.5%的项目。有必要对真正的跨文化测试的识别进行进一步研究。
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