Rizzo-Sierra Carlos V, Gonzalez-Castaño Alexander, Leon-Sarmiento Fidias E
NeuroniKaS Laboratory, Advanced Biomedical Research Center, Bogota, Colombia.
Corporación Universitaria Minuto de Dios, Bogota, Colombia.
Arq Neuropsiquiatr. 2014 Jan;72(1):72-7. doi: 10.1590/0004-282X20130182.
Motion sickness or kinetosis is the result of the abnormal neural output originated by visual, proprioceptive and vestibular mismatch, which reverses once the dysfunctional sensory information becomes coherent. The space adaptation syndrome or space sickness relates to motion sickness; it is considered to be due to yaw, pith, and roll coordinates mismatch. Several behavioural and pharmacological measures have been proposed to control these vestibular-associated movement disorders with no success. Galvanic vestibular stimulation has the potential of up-regulating disturbed sensory-motor mismatch originated by kinetosis and space sickness by modulating the GABA-related ion channels neural transmission in the inner ear. It improves the signal-to-noise ratio of the afferent proprioceptive volleys, which would ultimately modulate the motor output restoring the disordered gait, balance and human locomotion due to kinetosis, as well as the spatial disorientation generated by gravity transition.
晕动病或运动病是由视觉、本体感觉和前庭不匹配引发的异常神经输出的结果，一旦功能失调的感觉信息变得协调，这种情况就会逆转。空间适应综合征或太空病与晕动病有关；它被认为是由于偏航、俯仰和横滚坐标不匹配所致。已经提出了几种行为和药理学措施来控制这些与前庭相关的运动障碍，但均未成功。电前庭刺激有潜力通过调节内耳中与GABA相关的离子通道神经传递，上调由晕动病和太空病引起的紊乱的感觉运动不匹配。它提高了传入本体感觉冲动的信噪比，这最终会调节运动输出，恢复因晕动病导致的紊乱步态、平衡和人类运动，以及重力转换产生的空间定向障碍。
