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蜗牛家族成员引发上皮-间质转化的能力各不相同，因此它们促进乳腺上皮细胞肿瘤转化的能力也存在差异。

Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells.

作者信息

Gras Baptiste, Jacqueroud Laurent, Wierinckx Anne, Lamblot Christelle, Fauvet Frédérique, Lachuer Joël, Puisieux Alain, Ansieau Stéphane

机构信息

Inserm UMR-S1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France; LabEx DEVweCAN, Lyon, France; UNIV UMR1052, Lyon, France; Université de Lyon, Lyon, France; Centre Léon Bérard, Lyon, France.

Inserm UMR-S1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France; LabEx DEVweCAN, Lyon, France; UNIV UMR1052, Lyon, France; Université de Lyon, Lyon, France; Centre Léon Bérard, Lyon, France; ProfileXpert, Bron, France.

出版信息

PLoS One. 2014 Mar 17;9(3):e92254. doi: 10.1371/journal.pone.0092254. eCollection 2014.

DOI:10.1371/journal.pone.0092254
PMID:24638100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3956896/
Abstract

By fostering cell commitment to the epithelial-to-mesenchymal transition (EMT), SNAIL proteins endow cells with motility, thereby favoring the metastatic spread of tumor cells. Whether the phenotypic change additionally facilitates tumor initiation has never been addressed. Here we demonstrate that when a SNAIL protein is ectopically produced in non-transformed mammary epithelial cells, the cells are protected from anoikis and proliferate under low-adherence conditions: a hallmark of cancer cells. The three SNAIL proteins show unequal oncogenic potential, strictly correlating with their ability to promote EMT. SNAIL3 especially behaves as a poor EMT-inducer comforting the concept that the transcription factor functionally diverges from its two related proteins.

摘要

通过促进细胞向上皮-间质转化（EMT）的定向分化，SNAIL蛋白赋予细胞运动能力，从而有利于肿瘤细胞的转移扩散。这种表型变化是否还会促进肿瘤起始，此前从未有过相关研究。在此我们证明，当在未转化的乳腺上皮细胞中异位表达一种SNAIL蛋白时，细胞可免受失巢凋亡影响，并在低黏附条件下增殖：这是癌细胞的一个标志。三种SNAIL蛋白表现出不同的致癌潜能，与其促进EMT的能力严格相关。尤其SNAIL3表现为一种较差的EMT诱导因子，这支持了转录因子在功能上与其两种相关蛋白不同的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/017366d8573c/pone.0092254.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/51201f8b038c/pone.0092254.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/1b9e5de61aed/pone.0092254.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/daeff76f9adb/pone.0092254.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/43bb072abdf5/pone.0092254.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/b77ef99443de/pone.0092254.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/017366d8573c/pone.0092254.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/51201f8b038c/pone.0092254.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/1b9e5de61aed/pone.0092254.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/daeff76f9adb/pone.0092254.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/43bb072abdf5/pone.0092254.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/b77ef99443de/pone.0092254.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98ca/3956896/017366d8573c/pone.0092254.g006.jpg

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