Jenson A B, Kurman R J, Lancaster W D
Department of Pathology, Georgetown University School of Medicine, Washington, DC.
Clin Dermatol. 1985 Oct-Dec;3(4):56-63. doi: 10.1016/0738-081x(85)90049-5.
HPV infections are associated with many proliferative lesions of cutaneous and mucosal squamous epithelium. PV genus-specific (common) antigens can be detected by immunocytochemical techniques in approximately 50% of lesions (warts and papillomas) without dysplastic changes. Dysplastic lesions of squamous epithelium are less likely to be permissive for viral expression; squamous neoplasias are rarely, if ever, productively infected. Almost any tissue that has been processed for pathology or exfoliative cytologic preparations can be reliably stained for the presence of papillomavirus common antigens. A positive staining reaction is interpreted as meaning that the lesion is associated with HPV infection and that it has a potential for being contagious.
人乳头瘤病毒（HPV）感染与皮肤和黏膜鳞状上皮的许多增殖性病变相关。通过免疫细胞化学技术，在大约50%无发育异常改变的病变（疣和乳头状瘤）中可检测到PV属特异性（共同）抗原。鳞状上皮的发育异常病变不太可能允许病毒表达；鳞状上皮瘤即使有也很少发生有效感染。几乎任何经过病理处理或用于脱落细胞学检查的组织，都能可靠地检测乳头瘤病毒共同抗原的存在。阳性染色反应被解释为该病变与HPV感染相关且具有潜在传染性。
