不同供体神经端侧神经吻合治疗臂丛神经损伤的实验研究：大鼠模型实验
End-to-side neurotization with different donor nerves for treating brachial plexus injury: an experimental study in a rat model.
作者信息
Yang Wengbo, Yang Jianyun, Yu Cong, Gu Yudong
机构信息
Department of Hand Surgery Nanjing First Hospital, Nanjing, China.
出版信息
Muscle Nerve. 2014 Jul;50(1):67-72. doi: 10.1002/mus.24110. Epub 2014 May 9.
INTRODUCTION
End-to-side neurotization is currently used to treat brachial plexus injury, but it is not clear which donor nerve yields the best outcome. We performed experiments to determine the optimal donor nerve.
METHODS
A total of 66 male Sprague-Dawley rats were assigned to 1 of 3 groups. Group A was the control group. In Group B, the phrenic nerve was used as the donor, while the ipsilateral C7 nerve root served as the donor in Group C. The epineurial window was used in end-to-side neurorrhaphy. Behavioral observations, histology, electrophysiology, and fluorescence retrotracing were performed postoperatively.
RESULTS
Fluorescence retrotracing confirmed nerve regeneration in both Groups B and C upon end-to-side neurotization. The outcome of Group B was superior to that of Group C.
CONCLUSIONS
Use of the phrenic nerve as the donor nerve yielded a better outcome than use of the ipsilateral C7 nerve root.
引言
端侧神经吻合术目前用于治疗臂丛神经损伤，但尚不清楚哪种供体神经能产生最佳效果。我们进行了实验以确定最佳供体神经。
方法
总共66只雄性Sprague-Dawley大鼠被分为3组中的1组。A组为对照组。在B组中，使用膈神经作为供体，而在C组中，同侧C7神经根作为供体。端侧神经缝合术中使用了神经外膜开窗法。术后进行行为观察、组织学、电生理学和荧光逆行追踪。
结果
荧光逆行追踪证实B组和C组在端侧神经吻合术后均有神经再生。B组的结果优于C组。
结论
使用膈神经作为供体神经比使用同侧C7神经根产生更好的效果。
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