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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Taneike T, Miyazaki H, Oikawa S, Ohga A

Department of Veterinary Pharmacology, Faculty of Dairy Science, Rakuno Gakuen University, Ebetsu, Japan.

Gen Pharmacol. 1988;19(5):689-95. doi: 10.1016/0306-3623(88)90130-9.

The effects of compound 48/80 on cholinergic nerve transmission and on the liberation of histamine in the isolated chick oesophagus were investigated. 2. Compound 48/80 (0.2-1 microgram ml-1) potentiated the cholinergic nerve-induced contraction and caused the contraction of the oesophagus itself. The latter response was prevented by atropine, tetrodotoxin and mepyramine but not by metiamide. 3. Compound 48/80 released dose-dependently endogenous histamine from the isolated chick oesophagus. 4. These results suggest that the action of compound 48/80 is mediated by the release of histamine from an endogenous pool and that histamine released endogenously facilitates the release of ACh from the intrinsic cholinergic nerve in the chick oesophagus.

研究了化合物48/80对离体鸡食管胆碱能神经传递及组胺释放的影响。2. 化合物48/80（0.2 - 1微克/毫升）增强了胆碱能神经诱导的收缩，并引起食管自身收缩。后一种反应可被阿托品、河豚毒素和甲氧苄胺嘧啶阻断，但不能被甲硫米特阻断。3. 化合物48/80能剂量依赖性地从离体鸡食管释放内源性组胺。4. 这些结果表明，化合物48/80的作用是通过从内源性储备中释放组胺介导的，并且内源性释放的组胺促进了鸡食管中内在胆碱能神经释放乙酰胆碱。

Taneike T, Miyazaki H, Oikawa S, Ohga A

Department of Veterinary Pharmacology, Faculty of Dairy Science, Rakuno Gakuen University, Ebetsu, Japan.

Gen Pharmacol. 1988;19(5):689-95. doi: 10.1016/0306-3623(88)90130-9.

The effects of compound 48/80 on cholinergic nerve transmission and on the liberation of histamine in the isolated chick oesophagus were investigated. 2. Compound 48/80 (0.2-1 microgram ml-1) potentiated the cholinergic nerve-induced contraction and caused the contraction of the oesophagus itself. The latter response was prevented by atropine, tetrodotoxin and mepyramine but not by metiamide. 3. Compound 48/80 released dose-dependently endogenous histamine from the isolated chick oesophagus. 4. These results suggest that the action of compound 48/80 is mediated by the release of histamine from an endogenous pool and that histamine released endogenously facilitates the release of ACh from the intrinsic cholinergic nerve in the chick oesophagus.

研究了化合物48/80对离体鸡食管胆碱能神经传递及组胺释放的影响。2. 化合物48/80（0.2 - 1微克/毫升）增强了胆碱能神经诱导的收缩，并引起食管自身收缩。后一种反应可被阿托品、河豚毒素和甲氧苄胺嘧啶阻断，但不能被甲硫米特阻断。3. 化合物48/80能剂量依赖性地从离体鸡食管释放内源性组胺。4. 这些结果表明，化合物48/80的作用是通过从内源性储备中释放组胺介导的，并且内源性释放的组胺促进了鸡食管中内在胆碱能神经释放乙酰胆碱。