组胺对鸡食管（家鸡）胆碱能传递的增强作用。

Histamine-induced potentiation of cholinergic transmission in chick oesophagus (Gallus gallus).

Taneike T, Miyazaki H, Ohga A

Department of Veterinary Pharmacology, Faculty of Dairy Science, Rakuno Gakuen University, Ebetsu, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;89(2):271-6. doi: 10.1016/0742-8413(88)90223-x.

Abstract

The effects of histamine on cholinergic nerve transmission were investigated in the oesophagus of the chick (0-29 days old). 2. Histamine potentiated the contractile responses produced by vagal or transmural nerve stimulation and by the ganglionic stimulant (DMPP) with the increase of tonus of oesophagus. On the other hand, a selective H2 agonist, 4-methylhistamine, did not have any effect. 3. The sensitivity of oesophagus to ACh did not change in the presence of histamine (0.2-2 microM). 4. Mepyramine but not metiamide antagonized the contractile and potentiating effects of histamine. 5. From these findings, it is concluded that histamine preferentially acts on H1-receptors located in cholinergic neurones to facilitate cholinergic transmission in the chick oesophagus, potentiating the nerve-mediated contraction.

摘要

研究了组胺对雏鸡（0 - 29日龄）食管胆碱能神经传递的影响。2. 组胺增强了迷走神经或跨壁神经刺激以及神经节兴奋剂（二甲基苯基哌嗪，DMPP）所产生的收缩反应，同时食管张力增加。另一方面，选择性H2激动剂4 - 甲基组胺没有任何作用。3. 在存在组胺（0.2 - 2微摩尔）的情况下，食管对乙酰胆碱的敏感性没有改变。4. 甲氧苄胺嘧啶而非甲硫米特拮抗了组胺的收缩和增强作用。5. 从这些发现可以得出结论，组胺优先作用于胆碱能神经元中的H1受体，以促进雏鸡食管中的胆碱能传递，增强神经介导的收缩。