Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Richmond, VA, USA ; Department of Psychiatry, Virginia Commonwealth University Richmond, VA, USA ; Department of Psychology, Virginia Commonwealth University Richmond, VA, USA ; Department of Human and Molecular Genetics, Virginia Commonwealth University Richmond, VA, USA.
Department of Psychology, Virginia Commonwealth University Richmond, VA, USA ; Department of African American Studies, Virginia Commonwealth University Richmond, VA, USA.
Front Genet. 2014 Mar 6;5:47. doi: 10.3389/fgene.2014.00047. eCollection 2014.
Finding genes involved in complex behavioral outcomes, and understanding the pathways by which they confer risk, is a challenging task, necessitating large samples that are phenotypically well characterized across time. We describe an effort to create a university-wide research project aimed at understanding how genes and environments impact alcohol use and related substance use and mental health outcomes across time in college students. Nearly 70% of the incoming freshman class (N = 2715) completed on-line surveys, with 80% of the students from the fall completing spring follow-ups. 98% of eligible participants also gave DNA. The participants closely approximated the university population in terms of gender and racial/ethnic composition. Here we provide initial results on alcohol use outcomes from the first wave of the sample, as well as associated predictor variables. We discuss the potential for this kind of research to advance our understanding of genetic and environment influences on substance use and mental health outcomes.
发现与复杂行为结果相关的基因，并了解它们导致风险的途径，是一项具有挑战性的任务，需要大量的样本，这些样本在整个时间内都具有良好的表型特征。我们描述了一项创建全校范围研究项目的努力，旨在了解基因和环境如何影响大学生在整个时间内的酒精使用和相关物质使用以及心理健康结果。近 70%的新生（N=2715）完成了在线调查，其中 80%的秋季学生完成了春季随访。98%符合条件的参与者也提供了 DNA。这些参与者在性别和种族/族裔构成方面与大学人口非常接近。在这里，我们提供了该样本第一波的酒精使用结果以及相关预测变量的初步结果。我们讨论了这种研究对增进我们对遗传和环境对物质使用和心理健康结果影响的理解的潜力。
