Sehat Zahra, Goshetasbi Azita, Taheri Amin Mehdi
Avicenna Research Institute, Reproductive Biotechnology Research Center, Tehran, Iran.
Department of Family Health Iranian In States for Health Sciences Research, Tehran, Iran.
Iran J Reprod Med. 2013 Feb;11(2):127-32.
Considering the effect of preterm delivery in morbidity and mortality of newborns, its precaution and prevention is so important.
To investigate the association between second trimester maternal serum biomarkers (Human Chorionic Gonadotropin, Alpha-fetoprotein, Non-conjugated estrogen, Inhibin A) and pre-term delivery.
This is a historical cohort study that has been performed for 700 pregnant women, clients of Nilou Lab in the second trimester of pregnancy to take the Quad Marker test between March to September 2008. The information of mothers having required conditions to enter to study has been registered and after delivery, they called again to be interviewed. These data sets using statistical tests: chi-square test and Roc Curve was analysis.
There is a direct relationship between preterm delivery and increase of Alpha-fetoprotein (p=0.011) and inhibin A (p=0.03) serum level and. Also, there is an inverse relationship between the non-conjugated estrogen (p=0.002) serum level and preterm delivery. Moreover, there is not any relationship between the increase human chorionic gonadotropin (p=0.68) serum level and preterm delivery.
The increase in the Alpha-fetoprotein and Inhibin A and decrease in Non-conjugated estrogen serum levels in the second trimester of pregnancy lead to enhance the probability of preterm delivery. Moreover, if the current study is done with higher samples and different sampling environment, it may have different results.
鉴于早产对新生儿发病率和死亡率的影响，其预防措施至关重要。
探讨孕中期孕妇血清生物标志物（人绒毛膜促性腺激素、甲胎蛋白、非结合雌激素、抑制素A）与早产之间的关联。
这是一项历史性队列研究，对2008年3月至9月在Nilou实验室进行四联标志物检测的700名孕中期孕妇进行了研究。记录了符合研究条件的母亲的信息，分娩后再次致电进行访谈。使用卡方检验和Roc曲线分析这些数据集。
早产与甲胎蛋白（p = 0.011）和抑制素A（p = 0.03）血清水平升高之间存在直接关系。此外，非结合雌激素血清水平（p = 0.002）与早产之间存在负相关。而且，人绒毛膜促性腺激素血清水平升高（p = 0.68）与早产之间没有任何关系。
孕中期甲胎蛋白和抑制素A升高以及非结合雌激素血清水平降低会增加早产的可能性。此外，如果本研究采用更多样本和不同的采样环境进行，可能会有不同的结果。
