单核苷酸多态性与恶性和交界性骨肿瘤的关联。
Associations of single nucleotide polymorphisms with malignant and borderline bone tumors.
作者信息
Kushlinskii N E, Tivofeev Yu S, Generozov E V, Naumov V A, Soloviev Yu N, Boulytcheva I V, Aliev M D
出版信息
Klin Lab Diagn. 2013 Oct(10):58-60, 22-4.
Bone neoplasms - are a rare group of diseases, which ethiology and pathogenesis are not fully understood. We have studied 6 single nucleotide polymorphisms rs792/(GHI), rs7956547(IGFI), rs3761243(GNRH2), rs11737764(FGF2), rs6599400(FGFR3), and rs1690916(MDM2) associations with bone tumors. In our work we've detected significant associations with some single nucleotide polymorphisms: IGFl.rs7956547, GNRH2.rs3761243 and FGFR3.rs6599400 in patients with malignant and borderline bone tumors.
骨肿瘤是一类罕见的疾病，其病因和发病机制尚未完全明确。我们研究了6个单核苷酸多态性，即rs792/（GHI）、rs7956547（IGFI）、rs3761243（GNRH2）、rs11737764（FGF2）、rs6599400（FGFR3）和rs1690916（MDM2）与骨肿瘤的相关性。在我们的研究中，我们检测到某些单核苷酸多态性与恶性和交界性骨肿瘤患者存在显著相关性：IGFl.rs7956547、GNRH2.rs3761243和FGFR3.rs6599400。
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