Wadhwa A, Avasthi R, Ghambhir J K, Dwivedi S
J Assoc Physicians India. 2013 Jun;61(6):384-6.
To study the prevalence and profile of metabolic syndrome, levels of hs-CRP, Lp(a) and serum ferritin in young Indian patients (< or = 45 years) with acute MI.
A total of 80 subjects in two groups (40 cases and 40 controls) of age < or = 45 years were studied. Diagnosis of MI was made using the American College of Cardiology and European Society of Cardiology guidelines for acute MI. Patients were assessed for presence of MetS, diagnosed as per modified ATP III criteria. The anthropometric measurements (including height, weight, waist circumference) and sample collection for lipid profile, fasting blood sugar, hs-CRP, Lp(a) and serum ferritin were done after seventy two hours of admission.
The mean age for cases was 39.23 +/- 4.80 years and for controls it was 38.9 +/- 4.23 years. 19 (47.5%) patients out of 40 in group 1 fulfilled > or = 3/5 criteria for MetS while only 8 (20%) subjects in control group had MetS. Among five components of metabolic syndrome, increased waist circumference was most predominant factor followed by decreased HDL, increased TG, increased blood pressure and impaired fasting glucose. The mean value of serum ferritin was 279.33 +/- 46.69 mg in case group as compared to 245.15 +/- 56.94 in control group. hs-CRP (16.048 +/- 10.27 mg/l vs 1.8 +/- 1.6 mg/l) and Lp(a) (38.74 +/- 26.15 mg/dl vs 20.54 +/- 16.27 mg/dl) levels were significantly raised in cases as compared to control subjects.
The present study revealed high prevalence of metabolic syndrome (47.5%) in young patients with acute MI. Serum hsCRP, a diagnostic and prognostic novel marker of inflammation was also significantly elevated in cases. Its relationship with metabolic syndrome is also well established. Lp(a) and serum ferritin were also raised in cases.
研究年龄小于或等于45岁的印度急性心肌梗死患者代谢综合征的患病率及特征、超敏C反应蛋白（hs-CRP）、脂蛋白（a）[Lp（a）]和血清铁蛋白水平。
对两组共80名年龄小于或等于45岁的受试者（40例患者和40例对照）进行研究。心肌梗死的诊断采用美国心脏病学会和欧洲心脏病学会的急性心肌梗死指南。根据改良的ATP III标准评估患者是否存在代谢综合征（MetS）。入院72小时后进行人体测量（包括身高、体重、腰围），并采集血脂、空腹血糖、hs-CRP、Lp（a）和血清铁蛋白样本。
病例组的平均年龄为39.23±4.80岁，对照组为38.9±4.23岁。第1组40例患者中有19例（47.5%）符合MetS的≥3/5标准，而对照组中只有8例（20%）受试者患有MetS。在代谢综合征的五个组成部分中，腰围增加是最主要的因素，其次是高密度脂蛋白降低、甘油三酯升高、血压升高和空腹血糖受损。病例组血清铁蛋白的平均值为279.33±46.69mg，而对照组为245.
