Pillay A K, Naidoo D P
Department of Internal Medicine, University of KwaZulu-Natal, Durban, South Africa. Email:
Department of Cardiology, University of KwaZulu-Natal, Durban, South Africa.
Cardiovasc J Afr. 2018;29(1):36-42. doi: 10.5830/CVJA-2017-035. Epub 2017 Dec 12.
Few studies have evaluated young adults in their third and fourth decades with coronary artery disease (CAD). This study evaluated the clinical and angiographic profile of young adults ( < 35 years) with CAD.
A 10-year (2003-2012) retrospective chart review was performed on patients less than 35 years diagnosed with CAD at Inkosi Albert Luthuli Central Hospital, Durban.
Of the 100 patients who met the study criteria, the majority were male (90%), of Indian ethnicity (79%), and presented with acute coronary syndrome (93%). Smoking (82%), dyslipidaemia (79%) and dysglycaemia (75%) were the most prevalent risk factors. Almost half of the subjects (48%) met criteria for the metabolic syndrome. Angiographic findings revealed multi-vessel (42%), single-vessel (36%) and non-occlusive disease (20%); only two subjects had normal epicardial vessels. Disease severity was influenced by dyslipidaemia (p = 0.002) and positive family history (p = 0.002). Non-coronary aetiologies were identified in 19% of subjects.
Atherosclerotic disease associated with risk-factor clustering was highly prevalent in young adults with CAD.
很少有研究评估三四十岁的冠心病（CAD）青年患者。本研究评估了患有CAD的青年（<35岁）患者的临床和血管造影特征。
对德班因科西·阿尔伯特·卢图利中心医院诊断为CAD的35岁以下患者进行了为期10年（2003 - 2012年）的回顾性病历审查。
在符合研究标准的100例患者中，大多数为男性（90%），印度裔（79%），并表现为急性冠状动脉综合征（93%）。吸烟（82%）、血脂异常（79%）和血糖异常（75%）是最常见的危险因素。几乎一半的受试者（48%）符合代谢综合征标准。血管造影结果显示多支血管病变（42%）、单支血管病变（36%）和非闭塞性病变（20%）；只有两名受试者心外膜血管正常。疾病严重程度受血脂异常（p = 0.002）和家族史阳性（p = 0.002）影响。19%的受试者发现有非冠状动脉病因。
与危险因素聚集相关的动脉粥样硬化疾病在患有CAD的青年中非常普遍。
