He Tao, Barker Matthew L, Biesbrock Aaron R, Eynon Holly, Milleman Jeffery L, Milleman Kimberly R, Putt Mark S, Wintergerst Ana María
Am J Dent. 2013 Dec;26(6):303-6.
To compare the relative plaque control efficacy of a marketed 0.454% stabilized stannous fluoride (SnF2) dentifrice relative to a triclosan/copolymer dentifrice using digital plaque imaging analysis (DPIA).
This was a randomized, two-treatment, double-blind, parallel group design study that compared SnF2 and triclosan/copolymer dentifrices over a period of 3 weeks. DPIA was used to capture a digital image of the maxillary and mandibular anterior facial surfaces of 12 teeth and to calculate plaque area coverage. Overnight DPIA images were taken at a baseline visit after which subjects were randomly assigned to one of the two treatment groups and were required to brush with their assigned dentifrice according to each manufacturer's instructions. Subjects had DPIA assessments on two separate days at the end of Week 3.
96 subjects were randomized to treatment. Plaque area data for 47 subjects per treatment group were compared at Week 3 using ANCOVA. The SnF2 group demonstrated a statistically significant reduction in overnight plaque at Week 3 compared to baseline (P= 0.002). The reduction for the triclosan group at Week 3 compared to baseline was not statistically significant (P= 0.24). At Week 3, the SnF2 group demonstrated a 17% lower adjusted mean for overnight plaque relative to the triclosan group with a mean difference that was statistically significant (P< 0.05). The Week 3 adjusted mean change from baseline in overnight plaque for the SnF2 group was 3 times greater versus that of the triclosan group (P< 0.05).
使用数字菌斑成像分析（DPIA）比较市售的0.454%稳定化氟化亚锡（SnF2）牙膏与含三氯生/共聚物牙膏的相对菌斑控制效果。
这是一项随机、双治疗、双盲、平行组设计研究，在3周时间内比较了SnF2牙膏和含三氯生/共聚物牙膏。使用DPIA获取12颗牙齿上颌和下颌前牙面部表面的数字图像，并计算菌斑面积覆盖率。在基线访视时拍摄夜间DPIA图像，之后受试者被随机分配到两个治疗组之一，并被要求按照各制造商的说明使用分配的牙膏刷牙。受试者在第3周结束时的两个不同日期进行DPIA评估。
96名受试者被随机分配接受治疗。在第3周时，使用协方差分析比较了每个治疗组47名受试者的菌斑面积数据。与基线相比，SnF2组在第3周时夜间菌斑有统计学显著减少（P = 0.002）。三氯生组在第3周时与基线相比的减少无统计学意义（P = 0.24）。在第3周时，SnF2组夜间菌斑的调整后均值比三氯生组低17%，平均差异有统计学意义（P < 0.05）。SnF2组在第3周时夜间菌斑相对于基线的调整后均值变化是三氯生组的3倍（P < 0.05）。
