Bellamy P G, Boulding A, Farmer S, Day T N, Mussett A J, Barker M L
Procter & Gamble, London Innovation Centre, Egham, Surrey, UK.
J Clin Dent. 2011;22(5):144-8.
To compare the plaque inhibition efficacy of a novel 0.454% stannous fluoride (SnF2) test dentifrice with sodium hexametaphosphate and stannous chloride to a chlorhexidine digluconate (0.05%), aluminium lactate (0.8%), and aluminium fluoride marketed control dentifrice (Lacalut Aktiv or AlF3/Chx).
This was a randomized, two-treatment, two-period, double-blind crossover study that compared the SnF2 test dentifrice to the AlF3/Chx control dentifrice. Each of the two treatment periods lasted for 17 consecutive days of product use, during which subjects were required to brush twice per day with their assigned dentifrice using a standard manual toothbrush (Oral-B P35 Indicator). The two periods of the crossover were separated by a four-day washout period. Plaque levels on the facial anterior tooth surfaces were evaluated and averaged among three assessment days at the end of each treatment period using digital plaque imaging analysis (DPIA). The evening prior to assessments, subjects only brushed lingual surfaces. Assessment time points were carried out in the morning following no morning brushing (A.M. pre-brush), following 40 seconds of brushing with the assigned dentifrice (A.M. post-brush), and in the afternoon (P.M.). The DPIA captured images were used to calculate and analyze visible plaque coverage.
Twenty-eight subjects were randomized and completed the study. At each assessment time point, the SnF2 test dentifrice demonstrated a statistically significant lower plaque level compared to the AlF3/Chx dentifrice: A.M. mean pre-brush 15.9% lower, p < 0.05; A.M. mean post-brush 22.2% lower, p < 0.05; P.M. mean 24.3% lower, p < 0.005.
Compared to the AlF3/Chx control dentifrice, the novel SnF2 test dentifrice significantly inhibited plaque regrowth overnight and during the day. Immediately after brushing there was also significantly less plaque coverage with the SnF2 test dentifrice.
比较一种新型0.454%氟化亚锡（SnF2）测试牙膏与六偏磷酸钠和氯化亚锡对葡萄糖酸洗必泰（0.05%）、乳酸铝（0.8%）以及市售含氟牙膏（Lacalut Aktiv或AlF3/Chx）的牙菌斑抑制效果。
这是一项随机、双处理、双周期、双盲交叉研究，将含SnF2的测试牙膏与AlF3/Chx对照牙膏进行比较。两个治疗周期各持续连续17天的产品使用期，在此期间，受试者需使用标准手动牙刷（欧乐B P35型电动牙刷）每天用指定牙膏刷牙两次。交叉的两个周期之间有四天的洗脱期。在每个治疗周期结束时，使用数字菌斑成像分析（DPIA）对上前牙唇面的菌斑水平进行评估，并在三个评估日进行平均。在评估前一晚，受试者仅刷舌面。评估时间点在早晨未刷牙后（上午刷牙前）、使用指定牙膏刷牙40秒后（上午刷牙后）以及下午进行。DPIA拍摄的图像用于计算和分析可见菌斑覆盖率。
28名受试者被随机分组并完成了研究。在每个评估时间点，与AlF3/Chx牙膏相比，含SnF2的测试牙膏的菌斑水平在统计学上显著更低：上午刷牙前平均低15.9%，p<0.05；上午刷牙后平均低22.2%，p<0.05；下午平均低24.3%，p<0.005。
与AlF3/Chx对照牙膏相比，新型含SnF2的测试牙膏在夜间和白天能显著抑制牙菌斑再生长。刷牙后，含SnF2的测试牙膏的菌斑覆盖率也显著更低。
