Lifschitz M H, Seilheimer D K, Wilson G S, Williamson W D, Thurber S A, Desmond M M
Department of Pediatrics, Baylor College of Medicine, Houston.
J Perinatol. 1987 Spring;7(2):127-32.
Fifty infants weighing 1,500 g or less at birth with a diagnosis of bronchopulmonary dysplasia (BPD) were followed to a mean age of 25 months to determine their clinical course and short-term neurodevelopmental outcome after discharge from the Neonatal Intensive Care Unit, and to identify possible predictive factors for outcome. Because study participation was voluntary, the subjects may not have represented the total population of BPD survivors. Occurrences of abnormalities were high: 11 hearing impaired, 10 legally blind, 14 cerebral palsy, and 23 abnormal development scores. Twenty-one subjects had feeding problems and weight was below the fifth percentile in 26. Home-oxygen therapy was required by 50 per cent of the subjects. Although severity of illness, duration of oxygen therapy and feeding problems were greater among those sent home on oxygen, their neurodevelopmental status did not differ from that of infants breathing room air by discharge. Factors associated with neurodevelopmental outcome were intracranial hemorrhage, pulmonary air leak, and length of hospital stay.
对50名出生时体重1500克及以下且诊断为支气管肺发育不良（BPD）的婴儿进行随访，直至平均年龄25个月，以确定其临床病程及从新生儿重症监护病房出院后的短期神经发育结局，并确定可能的结局预测因素。由于研究参与是自愿的，这些受试者可能并不代表所有BPD存活者。异常发生率很高：11名听力受损，10名法定失明，14名患有脑瘫，23名发育评分异常。21名受试者有喂养问题，26名体重低于第五百分位数。50%的受试者需要家庭氧疗。虽然那些出院时仍需吸氧的婴儿病情更严重、氧疗时间更长且喂养问题更多，但他们的神经发育状况与出院时呼吸室内空气的婴儿并无差异。与神经发育结局相关的因素有颅内出血、肺空气泄漏和住院时间。
