患有慢性肺病的极早产儿的早期运动和智力发育
Early motor and mental development in very preterm infants with chronic lung disease.
作者信息
Katz-Salamon M, Gerner E M, Jonsson B, Lagercrantz H
机构信息
Department of Women and Child Health, Karolinska Institute, Stockholm, Sweden.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2000 Jul;83(1):F1-6. doi: 10.1136/fn.83.1.f1.
BACKGROUND
The increased incidence of neurological deviations in preterm infants with chronic lung disease (CLD) has been linked to severe brain haemorrhage (intraventricular haemorrhage (IVH)) and periventricular leucomalacia (PVL) rather than to CLD per se.
AIM
To evaluate whether CLD without concomitant brain lesions constitutes a risk factor for adverse developmental outcome.
METHOD
Forty three very low birthweight infants with CLD, but without IVH or PVL, and 43 very low birthweight infants without CLD, IVH, or PVL were evaluated at 5 and 10 months of corrected age using the movement assessment of infants (MAI) scale. The Griffiths' developmental test was carried out at 10 months of age.
RESULTS
The overall motor assessments (MAI) in infants with CLD and controls were not significantly different. However, differences were observed in the execution of volitional movements (MAI), the total sum, hand and eye coordination, and perception and intelligence (measured by the performance scale of the Griffiths' test).
CONCLUSIONS
CLD has a deleterious effect on the control of hand and eye coordination and on perception and intelligence. These results thus re-emphasise the necessity for careful neurodevelopmental follow up of infants with CLD whether or not they suffered IVH or PVL.
背景
慢性肺病（CLD）早产儿神经功能偏差发生率增加与严重脑内出血（脑室内出血（IVH））和脑室周围白质软化（PVL）有关，而非CLD本身。
目的
评估无伴随脑损伤的CLD是否构成不良发育结局的危险因素。
方法
对43例患有CLD但无IVH或PVL的极低出生体重儿和43例无CLD、IVH或PVL的极低出生体重儿在矫正年龄5个月和10个月时使用婴儿运动评估（MAI）量表进行评估。在10个月大时进行格里菲斯发育测试。
结果
CLD婴儿和对照组的总体运动评估（MAI）无显著差异。然而，在意志运动执行（MAI）、总分、手眼协调以及感知和智力（通过格里菲斯测试的表现量表测量）方面观察到差异。
结论
CLD对手眼协调控制以及感知和智力有有害影响。因此，这些结果再次强调了对患有CLD的婴儿进行仔细的神经发育随访的必要性，无论他们是否患有IVH或PVL。
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