Weiss Gerson
Ital J Anat Embryol. 2013;118(1 Suppl):17-8.
In primate pregnancy, circulating relaxin, solely a product of the corpus luteum, peaks in the first trimester of pregnancy then declines and levels off for the remainder of pregnancy. Relaxin actions in pregnancy include increasing cervical pro-MMP-1 and pro-MMP-3 and decreasing TIMP-1, changes which soften the cervix. Relaxin, from early pregnancy, increases endometrial natural killer cells, macrophages and neutrophils, blood flow and arterial number. Hyperrelaxinemia correlates with preterm birth.
在灵长类动物妊娠期间，循环中的松弛素仅由黄体产生，在妊娠的前三个月达到峰值，然后下降，并在妊娠剩余时间保持稳定。松弛素在妊娠中的作用包括增加宫颈前基质金属蛋白酶-1和前基质金属蛋白酶-3，以及降低金属蛋白酶组织抑制因子-1，这些变化会使宫颈变软。从妊娠早期开始，松弛素会增加子宫内膜自然杀伤细胞、巨噬细胞和中性粒细胞、血流量和动脉数量。高松弛素血症与早产相关。
