Goldsmith Laura T
Ital J Anat Embryol. 2013;118(1 Suppl):19-20.
Elucidating the role(s) of relaxin in women has been greatly hampered by its species specificity. Suitable experimental models of relaxin action in women are limited. We established a non-human primate model of early human pregnancy to study the effects of relaxin in vivo and used three well characterized in vitro models of human endometrial function for study of mechanisms involved. Results from these studies clearly demonstrate that relaxin is an import ant factor in human endometrium which causes accommodation to and maintenance of early pregnancy and uses multiple physiological and biochemical mediators.
由于松弛素的物种特异性，阐明其在女性体内的作用受到了极大阻碍。适合研究女性体内松弛素作用的实验模型有限。我们建立了一个早期人类妊娠的非人类灵长类动物模型来研究松弛素在体内的作用，并使用了三种特征明确的人类子宫内膜功能体外模型来研究其中涉及的机制。这些研究结果清楚地表明，松弛素是人类子宫内膜中的一个重要因子，它能促进早期妊娠并维持妊娠，且作用于多种生理和生化介质。
