Barbieri Maria Teresa, Cocco Maria Elisabetta, Cocco P
Med Lav. 2013 Nov-Dec;104(6):460-6.
Occupational allergic contact dermatitis (OACD), to which atopy contributes to a as yet unspecified degree, accounts for a considerable number of work-related diseases.
We studied the prevalence of atopy in OACD patients. We also compared the ability of prick tests and specific IgE assays to detect it.
In 329 patients diagnosed with OACD at the Occupational Medicine Unit of Cagliari University Hospital between 2000 and 2009, we aimed at detecting atopic conditions with prick tests and IgE assays specific for allergens most frequently responsible for atopic reaction. A kappa test was used to assess concordance between the two assays. The 2 test for trend was used in the analysis of prevalence of atopy by age at diagnosis.
A positive response was more frequently detected with prick tests (35.9%) than the specific IgE assays (31%). IgE assays for all the allergens we tested were more frequently positive among males (p range = 0.001-0.037). With either test, the highest observed prevalence of a positive response was to Dermatophagoides pteronyssinus. A significantly inverse trend with increasing age in the prevalence ofpositive reaction to Dermatophagoides pteronyssinus, Phleum pratense and Olea europaea (olive) allergens was also observed. The concordance between the two tests ranged between good (Dermatophagoides pteronyssinus, Phleum pratense and Olea europaea and moderate Artemisia vulgaris (mugwort) and Parietaria judaica.
Our results showed a prevalence of atopic conditions in 31-35.9% of OACD patients.
with the two assays were largely consistent, indicating that both prick tests an specific IgE assays are valid diagnostic tools for atopy.
职业性变应性接触性皮炎（OACD）在相当数量的与工作相关疾病中占一定比例，特应性在其中的作用程度尚不明确。
我们研究了OACD患者中特应性的患病率。我们还比较了点刺试验和特异性IgE检测对其的检测能力。
2000年至2009年间，在卡利亚里大学医院职业医学科诊断为OACD的329例患者中，我们旨在通过点刺试验和针对最常引起特应性反应的过敏原的IgE检测来检测特应性状况。使用kappa检验评估两种检测方法之间的一致性。在分析诊断时年龄与特应性患病率的关系时，使用趋势检验。
点刺试验（35.9%）比特异性IgE检测（31%）更常检测到阳性反应。我们检测的所有过敏原的IgE检测在男性中更常呈阳性（p值范围=0.001 - 0.037）。两种检测中，观察到对屋尘螨的阳性反应患病率最高。还观察到对屋尘螨、梯牧草和油橄榄（橄榄）过敏原的阳性反应患病率随年龄增长呈显著负相关趋势。两种检测之间的一致性在良好（屋尘螨、梯牧草和油橄榄）和中等（艾蒿和墙草）之间。
我们的结果显示31% - 35.9%的OACD患者存在特应性状况。
两种检测方法的结果基本一致，表明点刺试验和特异性IgE检测都是特应性的有效诊断工具。
