Yusof Nazri Mohd, Khalid Kamarul Ariffin, Zulkifly Ahmad Hafiz, Zakaria Zamzuri, Amin Mohammad Azril Mohammad, Awang Muhammad Shukimi, Ahmad Aminudin Che, Akter Sheikh Farid Uddin
Department of Orthopaedics, Traumatology and Rehabilitation, Kulliyyah of Medicine, International Islamic University Malaysia, Jalan Hospital, 25150 Kuantan, Pahang, Malaysia.
Department of Community Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia.
Malays J Med Sci. 2013 Oct;20(5):47-53.
Although open tibial fractures are common in Malaysia, the outcomes for these patients have not been evaluated in the literature. This retrospective study was conducted to examine the factors associated with infection and non-union in open tibial fractures managed at Hospital Tengku Ampuan Afzan (HTAA), Kuantan, in 2009.
From 1 January until 31 December 2009, the Department of Orthopaedics of HTAA managed 58 patients with open tibial fracture who had a minimum of a one year follow-up period. The median age was 24.5 years (range: 4 to 72 years). The open tibial fractures were graded using the Gustilo open fracture classification as follows: 4 grade I, 21 grade II, 24 grade IIIA and 9 grade IIIB. All open fractures were subjected to a standard treatment protocol at HTAA, which includes the use of prophylactic antibiotics, emergency debridement, fracture stabilisation, wound coverage, and bone reconstruction when required. The mean time from injury to the initial debridement was 29.7 hours (range: 13 to 216 hours).
Seventeen (29%) cases were complicated by infection, and 10 patients (17%) developed non-union. The grade of the open fracture was significantly associated with infection, and age and the time interval between the injury and the initial wound debridement were significantly associated with non-union.
The high rates of infection and non-union, particularly in severe open fractures, indicate that there is a need to improve the management of open tibial fractures treated at HTAA. The time to initial debridement is an important factor that can be readily amended to improve the outcome. Further studies with larger sample sizes are likely needed to replicate and confirm our findings.
尽管开放性胫骨骨折在马来西亚很常见,但文献中尚未对这些患者的治疗结果进行评估。本回顾性研究旨在探讨2009年在关丹的腾库安潘阿夫赞医院(HTAA)接受治疗的开放性胫骨骨折患者发生感染和骨不连的相关因素。
2009年1月1日至12月31日,HTAA骨科治疗了58例开放性胫骨骨折患者,这些患者至少接受了一年的随访。中位年龄为24.5岁(范围:4至72岁)。开放性胫骨骨折采用 Gustilo 开放性骨折分类法进行分级,具体如下:I级4例,II级21例,IIIA级24例,IIIB级9例。所有开放性骨折患者在HTAA均接受标准治疗方案,包括使用预防性抗生素、急诊清创、骨折固定、伤口覆盖以及必要时的骨重建。受伤至初次清创的平均时间为29.7小时(范围:13至216小时)。
17例(29%)发生感染并发症,10例(17%)出现骨不连。开放性骨折的分级与感染显著相关,年龄以及受伤与初次伤口清创之间的时间间隔与骨不连显著相关。
感染和骨不连的发生率较高,尤其是在严重开放性骨折中,这表明需要改进HTAA对开放性胫骨骨折的治疗。初次清创时间是一个重要因素,可以很容易地加以调整以改善治疗结果。可能需要进一步开展更大样本量的研究来重复和证实我们的研究结果。