用于生物成像的荧光蛋白和具有发光的环金属化铱(III)配合物的肽和蛋白质的位点选择性生物缀合。
Phosphorescent proteins for bio-imaging and site selective bio-conjugation of peptides and proteins with luminescent cyclometalated iridium(III) complexes.
机构信息
State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
出版信息
Chem Commun (Camb). 2014 Apr 28;50(33):4375-8. doi: 10.1039/c3cc48376b.
PMID:24643302
Abstract
A new bio-conjugation reaction for site selective modification of proteins and peptides with phosphorescent iridium(III) complexes has been developed; the Ir(III)-modified proteins and peptides display long emission lifetimes and large Stoke shifts that can be used for bio-imaging studies.
摘要
已经开发出一种新的生物缀合反应，用于对蛋白质和肽进行位点选择性修饰，带有磷光铱（III）配合物; Ir（III）修饰的蛋白质和肽显示出长的发射寿命和大的斯托克斯位移，可用于生物成像研究。
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