选择性同型半胱氨酸开启型荧光探针及其生物成像应用。
Selective homocysteine turn-on fluorescent probes and their bioimaging applications.
作者信息
Lee Hye Yeon, Choi Yoon Pyo, Kim Sunkyung, Yoon Taejin, Guo Zhiqian, Lee Songyi, Swamy K M K, Kim Gyoungmi, Lee Jin Yong, Shin Injae, Yoon Juyoung
机构信息
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea.
出版信息
Chem Commun (Camb). 2014 Jul 7;50(53):6967-9. doi: 10.1039/c4cc00243a.
The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.
本文描述了新型芘基荧光探针P-Hcy-1和P-Hcy-2的设计与开发，它们对同型半胱氨酸（Hcy）有选择性荧光增强响应。通过理论计算解释了P-Hcy-1和P-Hcy-2对Hcy与半胱氨酸（Cys）截然不同的荧光响应。最后，细胞实验结果表明这些探针可用于选择性检测哺乳动物细胞中的Hcy。
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