Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Wiley Interdiscip Rev Syst Biol Med. 2014 May-Jun;6(3):271-8. doi: 10.1002/wsbm.1265. Epub 2014 Mar 18.
Palatogenesis, the formation of the palate, is a dynamic process regulated by a complex series of context-dependent morphogenetic signaling events. Many genes involved in palatogenesis have been discovered through the use of genetically manipulated mouse models as well as from human genetic studies, but the roles of these genes and their products in signaling networks regulating palatogenesis are still poorly known. In this review, we give a brief overview on palatogenesis and introduce key signaling cascades leading to formation of the intact palate. Moreover, we review conceptual differences between pathway biology and network biology and discuss how some of the recent technological advances in conjunction with mouse genetic models have contributed to our understanding of signaling networks regulating palate growth and fusion. For further resources related to this article, please visit the WIREs website.
The authors have declared no conflicts of interest for this article.
palateogenesis，即腭的形成，是一个由一系列复杂的、依赖上下文的形态发生信号事件调节的动态过程。许多参与 palateogenesis 的基因已经通过使用遗传操作的小鼠模型以及人类遗传研究被发现，但这些基因及其产物在调节 palateogenesis 的信号转导网络中的作用仍知之甚少。在这篇综述中，我们简要概述了 palateogenesis，并介绍了导致完整腭形成的关键信号级联反应。此外，我们还回顾了通路生物学和网络生物学之间的概念差异，并讨论了最近的一些技术进步如何结合小鼠遗传模型，促进了我们对调节腭生长和融合的信号转导网络的理解。有关本文的更多资源，请访问 WIREs 网站。
作者声明本文没有利益冲突。
