三环类丙咪嗪对单独饲养大鼠下丘脑5-羟色胺、其前体及酸性分解代谢产物昼夜节律的影响

Tricyclic imipramine modification of the circadian rhythms of hypothalamic serotonin, its precursors and acid catabolite in individually housed rats.

作者信息

Greco A M, Gambardella P, Sticchi R, D'Aponte D, de Franciscis P

机构信息

Institute of Human Physiological Sciences, Second Medical School, University of Naples, Italy.

出版信息

Chronobiol Int. 1988;5(3):217-25. doi: 10.3109/07420528809079563.

DOI:10.3109/07420528809079563

PMID:2464441

Abstract

Circadian rhythms of serotonin (5HT), its precursors tryptophan (TP) and 5-hydroxy-tryptophan (5HTP) and its acid catabolite 5-hydroxy-indoleacetic acid (5HIAA), were determined in the hypothalamus of control rats and rats which had been treated continuously with subcutaneous imipramine (10 mg/kg/day) for 2 weeks. Rats were individually housed and entrained to LD 12:12. Controls showed the 5HT and TP peaks in the light and dark periods respectively, as reported in the literature, but no inverted correlation (antiphase) between 5HT and 5HIAA rhythms. Imipramine significantly modified circadian rhythm characteristics: the 5HT acrophase was advanced, that of TP and 5HIAA was delayed. Imipramine also significantly increased hypothalamic 5HT and TP concentrations.

摘要

在对照大鼠以及连续皮下注射丙咪嗪（10毫克/千克/天）两周的大鼠的下丘脑，测定了血清素（5-羟色胺，5HT）、其前体色氨酸（TP）和5-羟色氨酸（5HTP）以及其酸性分解代谢产物5-羟吲哚乙酸（5HIAA）的昼夜节律。大鼠单独饲养并适应12小时光照：12小时黑暗的周期。如文献报道，对照组分别在光照期和黑暗期出现5HT和TP峰值，但5HT和5HIAA节律之间无反向关联（反相）。丙咪嗪显著改变了昼夜节律特征：5HT的高峰期提前，TP和5HIAA的高峰期延迟。丙咪嗪还显著提高了下丘脑5HT和TP的浓度。