长期给予丙咪嗪可拮抗单独饲养大鼠紊乱的昼夜节律阶段。

Chronic administration of imipramine antagonizes deranged circadian rhythm phases in individually housed rats.

作者信息

Greco A M, Gambardella P, Sticchi R, D'Aponte D, De Franciscis P

机构信息

Istituto di Scienze Fisilogiche Umane, II Facoltà di Medicina e Chirurgia Università degli Studi di Napoli Federico II, Italy.

出版信息

Physiol Behav. 1990 Jul;48(1):67-72. doi: 10.1016/0031-9384(90)90262-3.

DOI:10.1016/0031-9384(90)90262-3

PMID:1700447

Abstract

The circadian rhythms of hypothalamic serotonin (5HT), tryptophan (TP) and 5-hydroxy-indoleacetic acid (5HIAA), and serum corticosterone were determined in male Wistar rats. The animals underwent a five-week 12:12-hr light/dark cycle conditioning period and were divided into three groups: rats housed four to a cage (group C, control), rats housed individually (group I), and rats housed individually and treated for two weeks with 10 mg/kg/day of imipramine continuously administered by osmotic pumps implanted under the skin (group T). Significant differences were found in the acrophases of 5HT, TP and 5HIAA between group I and group C, and corticosterone mesor was higher in group I than in group C. On the contrary, no differences were observed between group T (individually housed, but given imipramine) and group C. Therefore, chronically administered imipramine antagonizes the circadian changes induced by individual housing.

摘要

测定了雄性Wistar大鼠下丘脑5-羟色胺（5HT）、色氨酸（TP）和5-羟吲哚乙酸（5HIAA）的昼夜节律以及血清皮质酮水平。动物们经历了为期五周的12:12小时明暗循环适应期，并被分为三组：每笼饲养4只大鼠（C组，对照组）、单独饲养的大鼠（I组）以及单独饲养并用渗透泵皮下植入连续给予10mg/kg/天丙咪嗪治疗两周的大鼠（T组）。I组和C组之间5HT、TP和5HIAA的峰值相位存在显著差异，I组的皮质酮中值高于C组。相反，T组（单独饲养但给予丙咪嗪）和C组之间未观察到差异。因此，长期给予丙咪嗪可拮抗单独饲养引起的昼夜节律变化。