Alian Shahriar, Masoudzadeh Abbas, Khoddad Talayeh, Dadashian Amir, Ali Mohammadpour Reza
Department of infectious disease, Mazandaran university of Medical Science.
Psychiatry and Behavioral Sciences Research Center, Department of Psychiatriy, Mazandaran University of Medical Science, Sari, Iran.
Iran J Psychiatry Behav Sci. 2013 Spring;7(1):24-9.
Chronic infection of hepatitis B and hepatitis C are considered as the most important infectious diseases, which lead to drastic consequences such as liver dysfunction. Depression is a psychiatric disorder which is concomitantly present in these patients, and decreases the patients' quality of life. It may lead to suicide, homicide or intentional transmission of infectious to others. Medical treatment with interferon can also lead to depression which is comparable to the depression caused by disease.
We performed a cross sectional study on 205 patients with hepatitis B and hepatitis C infection. We aimed to determine the prevalence of depression via Beck Depression Inventory (BDI), and its correlates with hepatitis drugs.
Of 205 patients, 154 cases had hepatitis B and 51 cases had hepatitis C infection. The frequency of depression was 68% in hepatitis B and 86% in hepatitis C infected patients (p<0.05). The frequency of mild depression was 14%, moderate depression was 57.3% and severe depression was 28.7% (p<0.05). Depression frequency in Interferon recipients was 100%, in interferon-ribavirin recipients was 94.4%, in lamivudine recipients was 64%, and in patients that receive no drug was 66.7%. Depression prevalence was significantly higher among those on interferon therapy (p<0.05).
There is a high prevalence of depression among patients with hepatitis B and hepatitis C infection, especially patients on interferon therapy. Hence these patients should be repeatedly evaluated for depression.
None.
慢性乙型肝炎和丙型肝炎感染被认为是最重要的传染病，可导致肝功能障碍等严重后果。抑郁症是一种精神障碍，在这些患者中常伴随出现，会降低患者的生活质量。它可能导致自杀、杀人或故意将传染病传染给他人。使用干扰素进行药物治疗也可能导致抑郁症，其程度与疾病所致抑郁症相当。
我们对205例乙型和丙型肝炎感染患者进行了一项横断面研究。我们旨在通过贝克抑郁量表（BDI）确定抑郁症的患病率及其与肝炎药物的相关性。
205例患者中，154例患有乙型肝炎，51例患有丙型肝炎感染。乙型肝炎感染患者的抑郁症发生率为68%，丙型肝炎感染患者为86%（p<0.05）。轻度抑郁症的发生率为14%，中度抑郁症为57.3%，重度抑郁症为28.7%（p<0.05）。接受干扰素治疗的患者抑郁症发生率为100%，接受干扰素-利巴韦林治疗的患者为94.4%，接受拉米夫定治疗的患者为64%，未接受药物治疗的患者为66.7%。接受干扰素治疗的患者抑郁症患病率显著更高（p<0.05）。
乙型和丙型肝炎感染患者中抑郁症的患病率很高，尤其是接受干扰素治疗的患者。因此，应对这些患者反复进行抑郁症评估。
无。
