舍曲林与阿司匹林联合治疗对重度抑郁症患者抑郁严重程度的影响：一项随机临床试验。
The effects of combined sertraline and aspirin therapy on depression severity among patients with major depressive disorder: A randomized clinical trial.
作者信息
Sepehrmanesh Zahra, Fahimi Hosein, Akasheh Goudarz, Davoudi Mohamadreza, Gilasi Hamidreza, Ghaderi Amir
机构信息
M.D, Psychiatrist, Associate Professor, Department of Psychiatry, School of Medicine, Kashan University of Medical Science, Kashan, Iran.
M.D, Psychiatrist, Department of Psychiatry, School of Medicine, Kashan University of Medical Science, Kashan, Iran.
出版信息
Electron Physician. 2017 Nov 25;9(11):5770-5777. doi: 10.19082/5770. eCollection 2017 Nov.
BACKGROUND
Different studies have been conducted to find the best adjuvant therapies for depression management. There are controversies over the effects of aspirin as an adjuvant therapy for depression.
OBJECTIVE
To determine the effects of combined sertraline and aspirin therapy on depression severity among patients with major depressive disorder.
METHODS
This randomized clinical trial was conducted at Kargarnejad Psychiatric Hospital in Kashan, Isfahan, Iran, from September 1, 2016 to November 1, 2016. The study participants included 100 patients with major depressive disorder who were assigned to aspirin and placebo groups by the use of computer-generated random numbers. Patients in these groups respectively received sertraline-aspirin and sertraline-placebo for eight consecutive weeks. Patients were prescribed 80 milligrams of aspirin twice a day. Also, sertraline was administered at a dose of 50-200 milligrams daily. Beck Depression Inventory was employed for depression severity assessment at four time points, namely before, two, four, and eight weeks after the beginning of the intervention. Medication side effects were also assessed eight weeks after the beginning of the intervention. Data were analyzed by SPSS version 12.0, using Chi-square and the Independent-samples t-test (α=0.05).
RESULTS
Both groups were matched in terms of age (p=0.46), gender (p=0.539), and depression severity (p=0.509, with mean score 33.5±4.1 vs. 32.8±5.9) at baseline. However, depression scores were reduced significantly four and eight weeks after initiation of therapy just in the sertraline-aspirin group (p<0.05).
CONCLUSION
As an adjuvant therapy, aspirin can reduce depression severity among patients with major depressive disorder. Yet, further studies are needed to prove the effectiveness of aspirin and other anti-inflammatory agents in reducing depression severity.
TRIAL REGISTRATION
The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the IRCT ID: IRCT2016082829556N1.
FUNDING
The authors received financial support from Research Deputy of Kashan University of Medical Sciences, Kashan, Isfahan, Iran.
背景
已经开展了不同的研究来寻找治疗抑郁症的最佳辅助疗法。对于阿司匹林作为抑郁症辅助疗法的效果存在争议。
目的
确定舍曲林与阿司匹林联合治疗对重度抑郁症患者抑郁严重程度的影响。
方法
这项随机临床试验于2016年9月1日至2016年11月1日在伊朗伊斯法罕市卡尚的卡尔加内贾德精神病医院进行。研究参与者包括一百名重度抑郁症患者，通过计算机生成的随机数字将他们分配到阿司匹林组和安慰剂组两组之中。这些组中的患者分别连续八周接受舍曲林 - 阿司匹林和舍曲林 - 安慰剂治疗。患者每天服用两次80毫克的阿司匹林。此外，舍曲林的给药剂量为每日50 - 200毫克。在干预开始前、干预开始后两周四个月和八个月这四个时间点，采用贝克抑郁量表评估抑郁严重程度。在干预开始八周后还评估了药物副作用。使用SPSS 12.0版本进行数据分析，采用卡方检验和独立样本t检验(α = .).
结果
两组在基线时的年龄(p = 0.46)、性别(p = 0.539)和抑郁严重程度(p = 0.509，平均得分分别为33.5±4.1和32.8±5.9)方面相匹配。然而，仅在舍曲林 - 阿司匹林组中，治疗开始四周和八周后抑郁评分显著降低(p < 0.05)。
结论
作为一种辅助疗法，阿司匹林可以降低重度抑郁症患者的抑郁严重程度。然而，需要进一步的研究来证明阿司匹林和其他抗炎药在降低抑郁严重程度方面的有效性。
试验注册
该试验在伊朗临床试验注册中心（http://www.irct.ir）注册，IRCT编号为：IRCT2016082829556N1。
资金来源
作者获得了伊朗伊斯法罕市卡尚医科大学研究副院长的资金支持。
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