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本文引用的文献

1
Rituximab in adult patients with multi-relapsing/steroid-dependent minimal change disease and focal segmental glomerulosclerosis: a report of 5 cases.利妥昔单抗治疗成人复发性/激素依赖性微小病变肾病和局灶节段性肾小球硬化症:5 例报告
Wien Klin Wochenschr. 2013 Jun;125(11-12):328-33. doi: 10.1007/s00508-013-0366-7. Epub 2013 Apr 27.
2
Renal involvement in autoimmune connective tissue diseases.自身免疫性结缔组织病的肾脏受累。
BMC Med. 2013 Apr 4;11:95. doi: 10.1186/1741-7015-11-95.
3
Rituximab is an efficient and safe treatment in adults with steroid-dependent minimal change disease.利妥昔单抗治疗类固醇依赖型微小病变性肾病成人患者安全且有效。
Kidney Int. 2013 Mar;83(3):511-6. doi: 10.1038/ki.2012.444. Epub 2013 Jan 16.
4
Effect of single-dose rituximab on steroid-dependent minimal-change nephrotic syndrome in adults.利妥昔单抗单药治疗成人激素依赖型微小病变性肾病综合征的疗效。
Nephrol Dial Transplant. 2013 May;28(5):1225-32. doi: 10.1093/ndt/gfs515. Epub 2012 Dec 13.
5
Survey of rituximab treatment for childhood-onset refractory nephrotic syndrome.利妥昔单抗治疗儿童难治性肾病综合征的调查。
Pediatr Nephrol. 2013 Feb;28(2):257-64. doi: 10.1007/s00467-012-2319-1. Epub 2012 Oct 10.
6
Rituximab in steroid-dependent idiopathic nephrotic syndrome in childhood--follow-up after CD19 recovery.利妥昔单抗治疗儿童激素依赖型特发性肾病综合征-随访至 CD19 恢复后。
Nephrol Dial Transplant. 2012 Mar;27(3):1083-9. doi: 10.1093/ndt/gfr405. Epub 2011 Aug 1.
7
Prevention and treatment of systemic glucocorticoid side effects.防治全身糖皮质激素副作用。
Int J Dermatol. 2010 Mar;49(3):239-48. doi: 10.1111/j.1365-4632.2009.04322.x.
8
Rituximab in refractory nephrotic syndrome.利妥昔单抗治疗难治性肾病综合征。
Pediatr Nephrol. 2010 Mar;25(3):461-8. doi: 10.1007/s00467-009-1376-6. Epub 2009 Dec 23.
9
Anti-CD20 antibody is an efficient therapeutic tool for the selective removal of autoreactive T cells.抗CD20抗体是一种用于选择性清除自身反应性T细胞的有效治疗工具。
Nat Clin Pract Rheumatol. 2009 Feb;5(2):80-2. doi: 10.1038/ncprheum0983. Epub 2008 Dec 17.

肾病综合征;利妥昔单抗是成人激素依赖型微小病变病和局灶节段性肾小球硬化症治疗中的曙光吗?

Nephrotic syndrome; is rituximab the light at the end of the tunnel in the treatment of adult steroid-dependent minimal change disease and focal segmental glomerulosclerosis?

作者信息

Kronbichler Andreas, Mayer Gert

机构信息

Medical University Innsbruck, Department of Internal Medicine IV, Nephrology and Hypertension, Innsbruck, Austria.

出版信息

J Nephropathol. 2014 Jan;3(1):1-3. doi: 10.12860/jnp.2014.01. Epub 2014 Jan 1.

DOI:10.12860/jnp.2014.01
PMID:24644535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3956901/
Abstract

Implication for health policy/practice/research/medical education: Reports on patients with steroid-dependent nephrotic syndrome and underlying minimal change disease or focal segmental glomerulosclerosis have shown promising results. There is a strong need for more trials conducted in a prospective, controlled manner to clearly recommend rituximab therapy in this indication on a regular basis.

摘要

对卫生政策/实践/研究/医学教育的启示:关于依赖类固醇的肾病综合征及潜在微小病变病或局灶节段性肾小球硬化症患者的报告已显示出有前景的结果。迫切需要以前瞻性、对照方式开展更多试验,以便定期明确推荐利妥昔单抗用于这一适应症的治疗。