Nayer Ali
Division of Nephrology and Hypertension; University of Miami, USA.
J Nephropathol. 2014 Jan;3(1):26-8. doi: 10.12860/jnp.2014.06. Epub 2013 Aug 1.
Implication for health policy/practice/research/medical education: Amyloid A (AA) amyloidosis is a systemic form of amyloidosis secondary to chronic infections and inflammatory disorders such as recurrent suppurative skin infections secondaryto subcutaneous administration of drugs (skinpopping).The diagnosis of AA amyloidosis is frequently overlooked due to the insidious nature of the disease. The renal manifestations of AA amyloidosis include proteinuria, tubular dysfunction, and progressive loss of renal function. Urinalysis and quantification of urinary protein excretion are important screening tests. Early diagnosis and treatment of AA amyloidosis can reverse end-organ damage.
对卫生政策/实践/研究/医学教育的启示：淀粉样蛋白A（AA）淀粉样变性是一种继发于慢性感染和炎症性疾病（如因皮下注射药物（皮肤注射）引起的复发性化脓性皮肤感染）的全身性淀粉样变性。由于该疾病隐匿的性质，AA淀粉样变性的诊断常常被忽视。AA淀粉样变性的肾脏表现包括蛋白尿、肾小管功能障碍和肾功能的进行性丧失。尿液分析和尿蛋白排泄定量是重要的筛查测试。AA淀粉样变性的早期诊断和治疗可以逆转终末器官损伤。
