Chapman Michael David, Le Brian H C, Gorelik Alexandra
Centre for Palliative Care, Fitzroy, Australia.
BMJ Support Palliat Care. 2013 Sep;3(3):335-42. doi: 10.1136/bmjspcare-2012-000386. Epub 2013 Mar 13.
Frailty denotes a vulnerability to poor outcomes and is a common risk factor for mortality in older persons. The Vulnerable Elders Survey (VES) is an easy to administer validated screening tool to detect a frail population. Assessment of frailty has the potential to aid in prognostication for the older community dwelling palliative population. This study seeks to evaluate the relationship of the VES to prognosis in this population.
Prospective cohort study of patients over 65 years old admitted to a community palliative care service. The VES was performed in addition to the usual assessments of physical function. Comorbidity was assessed using the Charlson Comorbidity Index (CCI). Physical function and CCI were assessed to determine whether they improved the prognostic power of the VES. Patients were followed-up for 8 months with the primary endpoint of survival.
197 patients completed the study with a high proportion of malignant diagnoses (87.5%); 98% of patients died during the study with a median survival of 61 days; 93.4% of patients were vulnerable on the VES and high risk scores predicted death within 100 days.
In this study the VES demonstrated high rates of vulnerability and has the potential to improve the accuracy of prognosis in older palliative community dwelling patients. Improving prognostication has potential clinical benefits, including aiding clinical communication and determining the best use of community services. The limitations of this study and the evolving understanding of frailty suggest that further work in this area is required.
衰弱表示易出现不良后果,是老年人死亡的常见风险因素。脆弱老年人调查(VES)是一种易于实施的经过验证的筛查工具,用于检测衰弱人群。评估衰弱有可能有助于对社区居住的老年姑息治疗人群进行预后判断。本研究旨在评估VES与该人群预后的关系。
对入住社区姑息治疗服务机构的65岁以上患者进行前瞻性队列研究。除了常规的身体功能评估外,还进行了VES。使用Charlson合并症指数(CCI)评估合并症。评估身体功能和CCI,以确定它们是否提高了VES的预后预测能力。对患者进行了8个月的随访,主要终点为生存情况。
197名患者完成了研究,其中恶性诊断比例较高(87.5%);98%的患者在研究期间死亡,中位生存期为61天;93.4%的患者在VES评估中显示脆弱,高风险评分预测100天内死亡。
在本研究中,VES显示出较高的脆弱率,并且有可能提高社区居住的老年姑息治疗患者预后判断的准确性。改善预后判断具有潜在的临床益处,包括有助于临床沟通和确定社区服务的最佳使用方式。本研究的局限性以及对衰弱不断发展的认识表明,该领域需要进一步开展工作。