Harrison W M, McGrath P J, Stewart J W, Quitkin F
New York State Psychiatric Institute, New York.
J Clin Psychiatry. 1989 Feb;50(2):64-5.
The authors report several cases showing that use of over-the-counter (OTC) medications containing decongestants can cause hypertensive reactions in patients who are treated with monoamine oxidase inhibitors. Patient instructions accompanying OTC products (particularly those containing phenylpropanolamine) often omit specific warnings about the dangers of those products' concomitant use with MAOIs. Of further concern is the opportunity for patients to be confused by the similarity in names between some prohibited combination products and other more pharmacologically innocuous products that are acceptable for concomitant use.
作者报告了几例病例，表明使用含有减充血剂的非处方（OTC）药物会在接受单胺氧化酶抑制剂治疗的患者中引起高血压反应。OTC产品（尤其是那些含有苯丙醇胺的产品）附带的患者用药说明通常会忽略关于这些产品与单胺氧化酶抑制剂同时使用的危险的具体警告。更令人担忧的是，患者可能会因一些禁用组合产品与其他在药理学上更无害、可同时使用的产品之间名称相似而产生混淆。
