Pariante Carmine M
*Section of Perinatal Psychiatry and the Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Department of Psychological Medicine, King's College London, Room 2-055, The James Black Centre, 125 Coldharbour Lane, London SE5 9NU, U.K.
Biochem Soc Trans. 2014 Apr;42(2):582-6. doi: 10.1042/BST20130246.
Depression in pregnancy (also called 'antenatal depression') is being increasingly recognized as a clinically relevant condition that affects obstetric outcome, maternal behaviour and children's future mental health. The present review focuses on the molecular mechanisms operating in utero that underlie the potential effects of antenatal depression on mothers' and children's behaviour. In particular, I discuss evidence, coming largely from animal and cellular studies, that activation of the main hormonal stress-response system, the HPA (hypothalamic-pituitary-adrenal) axis, in mothers who are depressed during pregnancy may affect maternal care as well as offspring's behaviour and future psychopathology. The evidence summarized in the present review supports the notion that preventing or treating depression in pregnancy will alleviate not only the suffering of mothers, but also the suffering of the next generation.
孕期抑郁症（也称为“产前抑郁症”）越来越被视为一种具有临床相关性的病症，它会影响产科结局、母亲行为以及儿童未来的心理健康。本综述聚焦于子宫内起作用的分子机制，这些机制构成了产前抑郁症对母亲和儿童行为潜在影响的基础。特别地，我讨论了主要来自动物和细胞研究的证据，即在孕期抑郁的母亲中，主要的激素应激反应系统——下丘脑-垂体-肾上腺（HPA）轴的激活可能会影响母亲的照料行为以及后代的行为和未来的精神病理学状况。本综述总结的证据支持了这样一种观点，即预防或治疗孕期抑郁症不仅能减轻母亲的痛苦，还能减轻下一代的痛苦。
