从流行病学到病理生理学：阿尔茨海默病中的咖啡因情况如何？
From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?
作者信息
Flaten Vanessa, Laurent Cyril, Coelho Joana E, Sandau Ursula, Batalha Vânia L, Burnouf Sylvie, Hamdane Malika, Humez Sandrine, Boison Detlev, Lopes Luísa V, Buée Luc, Blum David
机构信息
‡Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisbon, Portugal.
§Legacy Research Institute, Portland, OR 97232, U.S.A.
出版信息
Biochem Soc Trans. 2014 Apr;42(2):587-92. doi: 10.1042/BST20130229.
Abstract
AD (Alzheimer's disease) is the most prevalent form of dementia in the aged population. Definitive diagnosis of AD is based on the presence of senile plaques and neurofibrillary tangles that are identified in post-mortem brain specimens. A third pathological component is inflammation. AD results from multiple genetic and environmental risk factors. Among other factors, epidemiological studies report beneficial effects of caffeine, a non-selective antagonist of adenosine receptors. In the present review, we discuss the impact of caffeine and the adenosinergic system in AD pathology as well as consequences in terms of pathology and therapeutics.
摘要
阿尔茨海默病（AD）是老年人群中最常见的痴呆形式。AD的确诊基于在死后脑标本中发现的老年斑和神经原纤维缠结。第三个病理成分是炎症。AD由多种遗传和环境风险因素引起。在其他因素中，流行病学研究报告了咖啡因（一种腺苷受体的非选择性拮抗剂）的有益作用。在本综述中，我们讨论了咖啡因和腺苷能系统对AD病理学的影响以及在病理学和治疗方面的后果。
相似文献
1
From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?从流行病学到病理生理学：阿尔茨海默病中的咖啡因情况如何？
Biochem Soc Trans. 2014 Apr;42(2):587-92. doi: 10.1042/BST20130229.
2
Purinergic receptors as potential therapeutic targets in Alzheimer's disease.嘌呤能受体作为阿尔茨海默病的潜在治疗靶点
Neuropharmacology. 2016 May;104:169-79. doi: 10.1016/j.neuropharm.2015.10.031. Epub 2015 Oct 28.
3
A Adenosine Receptor Antagonists in Neurodegenerative Diseases.腺嘌呤受体拮抗剂在神经退行性疾病中的应用。
Curr Med Chem. 2022;29(24):4138-4151. doi: 10.2174/0929867328666211129122550.
4
Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies.用于认知功能障碍的腺苷受体拮抗剂：动物研究综述
Front Biosci. 2008 Jan 1;13:2614-32. doi: 10.2741/2870.
5
Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: a review.使用咖啡因和其他腺苷受体拮抗剂和激动剂作为治疗神经退行性疾病的治疗工具：综述。
Life Sci. 2014 Apr 17;101(1-2):1-9. doi: 10.1016/j.lfs.2014.01.083. Epub 2014 Feb 13.
6
Purinergic signaling in Alzheimer's disease.嘌呤能信号在阿尔茨海默病中的作用。
Brain Res Bull. 2019 Sep;151:25-37. doi: 10.1016/j.brainresbull.2018.10.014. Epub 2018 Nov 22.
7
Caffeine for Prevention of Alzheimer's Disease: Is the A Adenosine Receptor Its Target?咖啡因预防阿尔茨海默病：A 腺苷受体是其靶点吗？
Biomolecules. 2023 Jun 8;13(6):967. doi: 10.3390/biom13060967.
8
Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production.咖啡因可保护患阿尔茨海默病的小鼠免受认知障碍，并减少大脑中β-淀粉样蛋白的产生。
Neuroscience. 2006 Nov 3;142(4):941-52. doi: 10.1016/j.neuroscience.2006.07.021. Epub 2006 Aug 28.
9
The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer's Disease.腺苷能信号传导：阿尔茨海默病复杂但有前景的治疗靶点
Front Neurosci. 2018 Aug 3;12:520. doi: 10.3389/fnins.2018.00520. eCollection 2018.
10
Adenosine receptors and caffeine in retinopathy of prematurity.早产儿视网膜病变中的腺苷受体与咖啡因
Mol Aspects Med. 2017 Jun;55:118-125. doi: 10.1016/j.mam.2017.01.001. Epub 2017 Jan 11.
引用本文的文献
1
Novel Quinazoline Derivatives as Highly Effective A2A Adenosine Receptor Antagonists.新型喹唑啉衍生物作为高效的 A2A 腺苷受体拮抗剂。
Molecules. 2024 Aug 14;29(16):3847. doi: 10.3390/molecules29163847.
2
Development of Functional Composite Edible Films or Coatings for Fruits Preservation with Addition of Pomace Oil-Based Nanoemulsion for Enhanced Barrier Properties and Caffeine for Enhanced Antioxidant Activity.开发具有果渣油基纳米乳液增强阻隔性能和咖啡因增强抗氧化活性的功能性复合可食用薄膜或涂层，用于水果保鲜。
Molecules. 2024 Aug 8;29(16):3754. doi: 10.3390/molecules29163754.
3
Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice.神经元A2A受体加剧APP/PS1小鼠的突触丢失和记忆缺陷。
Brain. 2024 Aug 1;147(8):2691-2705. doi: 10.1093/brain/awae113.
4
Divergent Effects of the Nonselective Adenosine Receptor Antagonist Caffeine in Pre-Manifest and Motor-Manifest Huntington's Disease.非选择性腺苷受体拮抗剂咖啡因在临床前和运动性亨廷顿病中的不同作用
Biomedicines. 2022 May 27;10(6):1258. doi: 10.3390/biomedicines10061258.
5
Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription.咖啡因摄入对海马代谢和学习相关转录产生全基因组的双重影响。
J Clin Invest. 2022 Jun 15;132(12). doi: 10.1172/JCI149371.
6
The Emerging Roles of the β-Secretase BACE1 and the Long Non-coding RNA BACE1-AS in Human Diseases: A Focus on Neurodegenerative Diseases and Cancer.β-分泌酶BACE1和长链非编码RNA BACE1-AS在人类疾病中的新作用：聚焦神经退行性疾病和癌症
Front Aging Neurosci. 2022 Mar 21;14:853180. doi: 10.3389/fnagi.2022.853180. eCollection 2022.
7
Early-Life Environment Influence on Late-Onset Alzheimer's Disease.早年生活环境对晚发性阿尔茨海默病的影响
Front Cell Dev Biol. 2022 Feb 17;10:834661. doi: 10.3389/fcell.2022.834661. eCollection 2022.
8
Potential of Caffeine in Alzheimer's Disease-A Review of Experimental Studies.咖啡因在阿尔茨海默病中的潜力——实验研究综述。
Nutrients. 2021 Feb 6;13(2):537. doi: 10.3390/nu13020537.
9
History of Coffee Consumption and Risk of Alzheimer's Disease: a Meta-epidemiological Study of Population-based Cohort Studies.咖啡消费史与阿尔茨海默病风险：基于人群队列研究的Meta流行病学研究
Dement Neurocogn Disord. 2020 Sep;19(3):108-113. doi: 10.12779/dnd.2020.19.3.108.
10
Caffeine exposure ameliorates acute ischemic cell death in avian developing retina.咖啡因暴露可减轻禽类发育中视网膜的急性缺血性细胞死亡。
Purinergic Signal. 2020 Mar;16(1):41-59. doi: 10.1007/s11302-020-09687-1. Epub 2020 Feb 20.
本文引用的文献
1
Progressive age-related cognitive decline in tau mice.tau 小鼠认知功能进行性衰老相关下降。
J Alzheimers Dis. 2013;37(4):777-88. doi: 10.3233/JAD-130110.
2
Adenosine receptor antagonists including caffeine alter fetal brain development in mice.腺苷受体拮抗剂，包括咖啡因，会改变小鼠的胎儿大脑发育。
Sci Transl Med. 2013 Aug 7;5(197):197ra104. doi: 10.1126/scitranslmed.3006258.
3
Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease.淀粉样蛋白和tau 神经病理学在阿尔茨海默病的小鼠模型中对前额叶突触可塑性和认知表现有不同影响。
J Alzheimers Dis. 2013;37(1):109-25. doi: 10.3233/JAD-122296.
4
Association between caffeine intake and age at onset in Huntington's disease.咖啡因摄入与亨廷顿病发病年龄的关系。
Neurobiol Dis. 2013 Oct;58:179-82. doi: 10.1016/j.nbd.2013.05.013. Epub 2013 May 31.
5
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.饮食诱导肥胖对 τ 病理的有害影响与 τ 转基因小鼠的胰岛素抵抗无关。
Diabetes. 2013 May;62(5):1681-8. doi: 10.2337/db12-0866. Epub 2012 Dec 18.
6
TREM2 variants in Alzheimer's disease.TREM2 变体在阿尔茨海默病中的作用。
N Engl J Med. 2013 Jan 10;368(2):117-27. doi: 10.1056/NEJMoa1211851. Epub 2012 Nov 14.
7
NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.NMDA 受体功能障碍导致 Tau 转基因模型中海马突触传递中脑源性神经营养因子诱导的易化受损。
Aging Cell. 2013 Feb;12(1):11-23. doi: 10.1111/acel.12018. Epub 2012 Nov 23.
8
From A1 to A3 en passant through A(2A) receptors in the hippocampus: pharmacological implications.从 A1 到 A3，途经海马体中的 A(2A)受体：药理学意义。
CNS Neurol Disord Drug Targets. 2012 Sep;11(6):652-63. doi: 10.2174/187152712803581074.
9
Caffeine for treatment of Parkinson disease: a randomized controlled trial.咖啡因治疗帕金森病：一项随机对照试验。
Neurology. 2012 Aug 14;79(7):651-8. doi: 10.1212/WNL.0b013e318263570d. Epub 2012 Aug 1.
10
Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer's disease.外泌体对阿尔茨海默病中病变的朊病毒样传播的潜在贡献。
Front Physiol. 2012 Jul 5;3:229. doi: 10.3389/fphys.2012.00229. eCollection 2012.
Zotero 插件