Flaten Vanessa, Laurent Cyril, Coelho Joana E, Sandau Ursula, Batalha Vânia L, Burnouf Sylvie, Hamdane Malika, Humez Sandrine, Boison Detlev, Lopes Luísa V, Buée Luc, Blum David
‡Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisbon, Portugal.
§Legacy Research Institute, Portland, OR 97232, U.S.A.
Biochem Soc Trans. 2014 Apr;42(2):587-92. doi: 10.1042/BST20130229.
AD (Alzheimer's disease) is the most prevalent form of dementia in the aged population. Definitive diagnosis of AD is based on the presence of senile plaques and neurofibrillary tangles that are identified in post-mortem brain specimens. A third pathological component is inflammation. AD results from multiple genetic and environmental risk factors. Among other factors, epidemiological studies report beneficial effects of caffeine, a non-selective antagonist of adenosine receptors. In the present review, we discuss the impact of caffeine and the adenosinergic system in AD pathology as well as consequences in terms of pathology and therapeutics.
阿尔茨海默病（AD）是老年人群中最常见的痴呆形式。AD的确诊基于在死后脑标本中发现的老年斑和神经原纤维缠结。第三个病理成分是炎症。AD由多种遗传和环境风险因素引起。在其他因素中，流行病学研究报告了咖啡因（一种腺苷受体的非选择性拮抗剂）的有益作用。在本综述中，我们讨论了咖啡因和腺苷能系统对AD病理学的影响以及在病理学和治疗方面的后果。
