Monack D, Munoz J J, Peacock M G, Black W J, Falkow S
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.
J Infect Dis. 1989 Feb;159(2):205-10. doi: 10.1093/infdis/159.2.205.
Pertussis toxin is a principal determinant of virulence produced by Bordetella pertussis in the disease whooping cough and is the primary toxinogenic component of the pertussis vaccine. This toxin is not produced by the closely related species Bordetella parapertussis. Toxinogenic strains of B. parapertussis were constructed by the conjugative introduction of cloned pertussis toxin genes. These and analogous toxinogenic and nontoxinogenic strains of B. pertussis were assayed for their toxicity and reactogenic activities. Expression of active toxin by either Bordetella sp. correlated with the induction of leukocytosis, anaphylaxis, and histamine sensitivity.
百日咳毒素是百日咳博德特氏菌在百日咳疾病中产生的毒力的主要决定因素，也是百日咳疫苗的主要产毒成分。这种毒素不是由密切相关的副百日咳博德特氏菌产生的。通过接合导入克隆的百日咳毒素基因构建了产毒的副百日咳博德特氏菌菌株。对这些以及百日咳博德特氏菌类似的产毒和无毒菌株的毒性和反应原活性进行了测定。任何一种博德特氏菌属细菌表达活性毒素均与白细胞增多、过敏反应和组胺敏感性的诱导相关。
