抗CXCL13抗体可抑制幽门螺杆菌感染诱导的胃淋巴滤泡形成。
Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection.
作者信息
Yamamoto K, Nishiumi S, Yang L, Klimatcheva E, Pandina T, Takahashi S, Matsui H, Nakamura M, Zauderer M, Yoshida M, Azuma T
机构信息
Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Vaccinex, Inc. 1895 Mount Hope Avenue, Rochester, New York, USA.
出版信息
Mucosal Immunol. 2014 Sep;7(5):1244-54. doi: 10.1038/mi.2014.14. Epub 2014 Mar 19.
Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue (MALT) lymphomas. It is known that CXC chemokine ligand 13 (CXCL13) is highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients, but the pathway that links the activation of CXCL13 and the formation of gastric MALT lymphomas remains unclear. In this study, we examined whether CXCL13 neutralization would interfere with the formation of gastric lymphoid follicles including B cells, CD4+T cells, dendritic cells (DCs), and follicular DCs (FDCs) in germinal centers to determine the role of CXCL13 in the formation of B-cell aggregates after H. suis infection. Moreover, the expression of genes associated with the lymphoid follicle formation was also effectively suppressed by anti-CXCL13 antibody treatment. These results suggest that the upregulation of CXCL13 has an important role in the development of gastric MALT lymphomas and highlight the potential of anti-CXCL13 antibody for protection against Helicobacter-induced gastric diseases.
猪幽门螺杆菌可感染动物和人类的胃部，并能诱发胃黏膜相关淋巴组织（MALT）淋巴瘤。已知CXC趋化因子配体13（CXCL13）在感染幽门螺杆菌的小鼠和胃MALT淋巴瘤患者中高表达，但连接CXCL13激活与胃MALT淋巴瘤形成的途径仍不清楚。在本研究中，我们检测了CXCL13中和是否会干扰胃淋巴滤泡的形成，这些淋巴滤泡包括生发中心的B细胞、CD4 + T细胞、树突状细胞（DC）和滤泡树突状细胞（FDC），以确定CXCL13在猪幽门螺杆菌感染后B细胞聚集形成中的作用。此外，抗CXCL13抗体处理也有效抑制了与淋巴滤泡形成相关基因的表达。这些结果表明，CXCL13的上调在胃MALT淋巴瘤的发展中起重要作用，并突出了抗CXCL13抗体预防幽门螺杆菌诱导的胃部疾病的潜力。
Zotero 插件