Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Microbes Infect. 2011 Jul;13(7):697-708. doi: 10.1016/j.micinf.2011.02.007. Epub 2011 Mar 21.
"Helicobacter heilmannii" ("H. heilmannii"), which belongs to the genus Helicobacter, is a group of bacterial species that display a long spiral-shaped morphology. Recent studies have demonstrated that "H. heilmannii" type 1 is actually H. suis, which mainly colonizes the stomachs of various animals and humans. However, the influence of H. suis on gastric diseases remains to be fully elucidated. In this report, we revealed the relationship between natural H. suis infection and follicular gastritis in the pig stomachs. From sequence analysis of the 16S rRNA, urease A, and urease B genes, the presence of H. suis was confirmed in pig gastric lymphoid follicles, and this bacterium was named H. suis KB1. In addition, H. suis KB1 was inoculated into C57BL/6J mice, and the following mouse model of the pathogenesis of follicular gastritis by H. suis infection was established: H. suis KB1 colonizes the mouse stomach, and moreover, induces the development of lymphoid follicles and acquired immune responses characterized by the activation of B cells and CD4 positive cells. These results may lead to better understanding of the relationship between H. suis and gastric diseases, especially follicular gastritis; and furthermore, our findings emphasize the zoonotic aspects of animal-human infection by H. suis.
“海氏弯曲菌”（“H.heilmannii”）属于弯曲菌属，是一组具有长螺旋形形态的细菌。最近的研究表明，“H.heilmannii”1 型实际上是猪源弯曲菌，主要定植于各种动物和人类的胃部。然而，猪源弯曲菌对胃部疾病的影响仍有待充分阐明。在本报告中，我们揭示了自然感染猪源弯曲菌与猪胃滤泡性胃炎之间的关系。通过 16S rRNA、尿素酶 A 和尿素酶 B 基因的序列分析，证实了猪胃淋巴滤泡中存在猪源弯曲菌，并将该细菌命名为 H.suisKB1。此外，我们将 H.suisKB1 接种到 C57BL/6J 小鼠中，建立了猪源弯曲菌感染导致滤泡性胃炎发病机制的小鼠模型：H.suisKB1 定植于小鼠胃部，并诱导淋巴滤泡的发育和以 B 细胞和 CD4 阳性细胞激活为特征的获得性免疫反应。这些结果可能有助于更好地理解猪源弯曲菌与胃部疾病的关系，特别是滤泡性胃炎；此外，我们的发现强调了猪源弯曲菌在动物-人类感染中的人畜共患病方面。
