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Genetics: Closing the distance on obesity culprits.

作者信息

Gorkin David U, Ren Bing

机构信息

Ludwig Institute for Cancer Research, La Jolla, California 92093, USA.

1] Ludwig Institute for Cancer Research, La Jolla, California 92093, USA. [2] Department of Cellular and Molecular Medicine, University of California, La Jolla, USA.

出版信息

Nature. 2014 Mar 20;507(7492):309-10. doi: 10.1038/nature13212. Epub 2014 Mar 12.

DOI:10.1038/nature13212
PMID:24646989
Abstract
摘要

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本文引用的文献

1
Obesity-associated variants within FTO form long-range functional connections with IRX3.FTO基因内与肥胖相关的变异与IRX3形成远距离功能连接。
Nature. 2014 Mar 20;507(7492):371-5. doi: 10.1038/nature13138. Epub 2014 Mar 12.
2
A high-resolution map of the three-dimensional chromatin interactome in human cells.人类细胞三维染色质互作组的高分辨率图谱。
Nature. 2013 Nov 14;503(7475):290-4. doi: 10.1038/nature12644. Epub 2013 Oct 20.
3
Robust 4C-seq data analysis to screen for regulatory DNA interactions.稳健的 4C-seq 数据分析,用于筛选调控 DNA 相互作用。
Indications for potential parent-of-origin effects within the FTO gene.
FTO基因内潜在的亲本来源效应的指征。
PLoS One. 2015 Mar 20;10(3):e0119206. doi: 10.1371/journal.pone.0119206. eCollection 2015.
4
Signatures of natural selection at the FTO (fat mass and obesity associated) locus in human populations.人类群体中FTO(与脂肪量和肥胖相关)基因座的自然选择特征。
PLoS One. 2015 Feb 3;10(2):e0117093. doi: 10.1371/journal.pone.0117093. eCollection 2015.
5
Systematic fine-mapping of association with BMI and type 2 diabetes at the FTO locus by integrating results from multiple ethnic groups.通过整合多个种族群体的结果,对FTO基因座与体重指数和2型糖尿病的关联进行系统性精细定位。
PLoS One. 2014 Jun 30;9(6):e101329. doi: 10.1371/journal.pone.0101329. eCollection 2014.
Nat Methods. 2012 Oct;9(10):969-72. doi: 10.1038/nmeth.2173. Epub 2012 Sep 9.
4
Systematic localization of common disease-associated variation in regulatory DNA.调控 DNA 中常见疾病相关变异的系统定位。
Science. 2012 Sep 7;337(6099):1190-5. doi: 10.1126/science.1222794. Epub 2012 Sep 5.
5
The long-range interaction landscape of gene promoters.基因启动子的远程相互作用景观。
Nature. 2012 Sep 6;489(7414):109-13. doi: 10.1038/nature11279.
6
HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter.HERC2 rs12913832 通过减弱长距离增强子和 OCA2 启动子之间的染色质环形成来调节人类的色素沉着。
Genome Res. 2012 Mar;22(3):446-55. doi: 10.1101/gr.128652.111. Epub 2012 Jan 10.
7
Overexpression of Fto leads to increased food intake and results in obesity.Fto 基因的过度表达会导致食物摄入量增加,从而导致肥胖。
Nat Genet. 2010 Dec;42(12):1086-92. doi: 10.1038/ng.713. Epub 2010 Nov 14.
8
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.长程基因调控将 2 型糖尿病和肥胖风险相关的基因组区域与 HHEX、SOX4 和 IRX3 联系起来。
Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):775-80. doi: 10.1073/pnas.0911591107. Epub 2009 Dec 22.
9
Inactivation of the Fto gene protects from obesity.Fto基因失活可预防肥胖。
Nature. 2009 Apr 16;458(7240):894-8. doi: 10.1038/nature07848. Epub 2009 Feb 22.
10
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.全基因组关联扫描显示,FTO基因中的遗传变异与肥胖相关性状有关。
PLoS Genet. 2007 Jul;3(7):e115. doi: 10.1371/journal.pgen.0030115.