遗传学：缩小与肥胖元凶之间的差距。 - Suppr

Genetics: Closing the distance on obesity culprits.

作者信息

Gorkin David U, Ren Bing

机构信息

Ludwig Institute for Cancer Research, La Jolla, California 92093, USA.

1] Ludwig Institute for Cancer Research, La Jolla, California 92093, USA. [2] Department of Cellular and Molecular Medicine, University of California, La Jolla, USA.

出版信息

Nature. 2014 Mar 20;507(7492):309-10. doi: 10.1038/nature13212. Epub 2014 Mar 12.

DOI:10.1038/nature13212

PMID:24646989

Abstract

摘要

相似文献

Genetics: Closing the distance on obesity culprits.遗传学：缩小与肥胖元凶之间的差距。

Nature. 2014 Mar 20;507(7492):309-10. doi: 10.1038/nature13212. Epub 2014 Mar 12.

Obesity. BMI-associated genetic variants in FTO mastermind IRX3 expression.肥胖。FTO基因中与体重指数相关的基因变异主导IRX3的表达。

Nat Rev Endocrinol. 2014 Jun;10(6):313. doi: 10.1038/nrendo.2014.36. Epub 2014 Mar 25.

Obesity-associated variants within FTO form long-range functional connections with IRX3.FTO基因内与肥胖相关的变异与IRX3形成远距离功能连接。

Nature. 2014 Mar 20;507(7492):371-5. doi: 10.1038/nature13138. Epub 2014 Mar 12.

Obesity genetics and epigenetics: dissecting causality.肥胖遗传学与表观遗传学：剖析因果关系。

Circ Cardiovasc Genet. 2014 Jun;7(3):395-6. doi: 10.1161/CIRCGENETICS.114.000698.

Regulation of Fto/Ftm gene expression in mice and humans.小鼠和人类中Fto/Ftm基因表达的调控。

Am J Physiol Regul Integr Comp Physiol. 2008 Apr;294(4):R1185-96. doi: 10.1152/ajpregu.00839.2007. Epub 2008 Feb 6.

Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling.剪状同源盒 1（CUX1）调节脂肪质量和肥胖相关以及视网膜炎色素变性 GTP 酶调节蛋白相互作用蛋白 1 样（RPGRIP1L）基因的表达，并协调瘦素受体信号。

J Biol Chem. 2011 Jan 21;286(3):2155-70. doi: 10.1074/jbc.M110.188482. Epub 2010 Oct 31.

Obesity: Fat chance.肥胖：成功机会渺茫。

Nature. 2009 Feb 26;457(7233):1095. doi: 10.1038/4571095a.

FTO gains function.FTO 获得功能。

Nat Genet. 2010 Dec;42(12):1038-9. doi: 10.1038/ng1210-1038.

FTO effect on energy demand versus food intake.FTO 对能量需求与食物摄入的影响。

Nature. 2010 Apr 1;464(7289):E1; discussion E2. doi: 10.1038/nature08807.

FTO and obesity: mechanisms of association.FTO与肥胖：关联机制

Curr Diab Rep. 2014;14(5):486. doi: 10.1007/s11892-014-0486-0.

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A Theoretically-Grounded Investigation of Perceptions About Healthy Eating and mHealth Support Among African American Men and Women in New Orleans, Louisiana.路易斯安那州新奥尔良市非裔美国男性和女性对健康饮食和移动健康支持的认知的理论基础调查。

Fam Community Health. 2018 Apr/Jun;41 Suppl 2 Suppl, Food Insecurity and Obesity(Suppl 2 FOOD INSECURITY AND OBESITY):S15-S24. doi: 10.1097/FCH.0000000000000177.

Regulations of Adipocyte Phenotype and Obesity by IRX3. Positive or Negative?IRX3对脂肪细胞表型和肥胖的调控：正向还是负向？

EBioMedicine. 2017 Oct;24:7-8. doi: 10.1016/j.ebiom.2017.09.032. Epub 2017 Sep 25.

Indications for potential parent-of-origin effects within the FTO gene.FTO基因内潜在的亲本来源效应的指征。

PLoS One. 2015 Mar 20;10(3):e0119206. doi: 10.1371/journal.pone.0119206. eCollection 2015.

Signatures of natural selection at the FTO (fat mass and obesity associated) locus in human populations.人类群体中FTO（与脂肪量和肥胖相关）基因座的自然选择特征。

PLoS One. 2015 Feb 3;10(2):e0117093. doi: 10.1371/journal.pone.0117093. eCollection 2015.

Systematic fine-mapping of association with BMI and type 2 diabetes at the FTO locus by integrating results from multiple ethnic groups.通过整合多个种族群体的结果，对FTO基因座与体重指数和2型糖尿病的关联进行系统性精细定位。

PLoS One. 2014 Jun 30;9(6):e101329. doi: 10.1371/journal.pone.0101329. eCollection 2014.

本文引用的文献

Obesity-associated variants within FTO form long-range functional connections with IRX3.FTO基因内与肥胖相关的变异与IRX3形成远距离功能连接。

Nature. 2014 Mar 20;507(7492):371-5. doi: 10.1038/nature13138. Epub 2014 Mar 12.

A high-resolution map of the three-dimensional chromatin interactome in human cells.人类细胞三维染色质互作组的高分辨率图谱。

Nature. 2013 Nov 14;503(7475):290-4. doi: 10.1038/nature12644. Epub 2013 Oct 20.

Robust 4C-seq data analysis to screen for regulatory DNA interactions.稳健的 4C-seq 数据分析，用于筛选调控 DNA 相互作用。

Nat Methods. 2012 Oct;9(10):969-72. doi: 10.1038/nmeth.2173. Epub 2012 Sep 9.

Systematic localization of common disease-associated variation in regulatory DNA.调控 DNA 中常见疾病相关变异的系统定位。

Science. 2012 Sep 7;337(6099):1190-5. doi: 10.1126/science.1222794. Epub 2012 Sep 5.

The long-range interaction landscape of gene promoters.基因启动子的远程相互作用景观。

Nature. 2012 Sep 6;489(7414):109-13. doi: 10.1038/nature11279.

HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter.HERC2 rs12913832 通过减弱长距离增强子和 OCA2 启动子之间的染色质环形成来调节人类的色素沉着。

Genome Res. 2012 Mar;22(3):446-55. doi: 10.1101/gr.128652.111. Epub 2012 Jan 10.

Overexpression of Fto leads to increased food intake and results in obesity.Fto 基因的过度表达会导致食物摄入量增加，从而导致肥胖。

Nat Genet. 2010 Dec;42(12):1086-92. doi: 10.1038/ng.713. Epub 2010 Nov 14.

Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.长程基因调控将 2 型糖尿病和肥胖风险相关的基因组区域与 HHEX、SOX4 和 IRX3 联系起来。

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):775-80. doi: 10.1073/pnas.0911591107. Epub 2009 Dec 22.

Inactivation of the Fto gene protects from obesity.Fto基因失活可预防肥胖。

Nature. 2009 Apr 16;458(7240):894-8. doi: 10.1038/nature07848. Epub 2009 Feb 22.

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.全基因组关联扫描显示，FTO基因中的遗传变异与肥胖相关性状有关。

PLoS Genet. 2007 Jul;3(7):e115. doi: 10.1371/journal.pgen.0030115.

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Genetics: Closing the distance on obesity culprits.

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