[Selective inhibition by 3'-azido-2',3-dideoxythymidine-5'- triphosphate of reverse transcription in retrovirus A particles from the rat liver].

The data presented demonstrate that 3'-azido-2',3'-dideoxythymidine 5'-triphosphate [dTTP (3N3)] specifically inhibits reverse transcription of viral RNA in the endogenous retroviral A-type particles isolated from the rat liver. The inhibitory action of dTTP (3N3) is concerned the termination of DNA synthesis obviously due to the incorporation of this dideoxynucleotide into the 3'-end of the growing DNA chain.