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[3'-叠氮-2',3'-双脱氧胸苷-5'-三磷酸对大鼠肝脏逆转录病毒A颗粒逆转录的选择性抑制作用]

[Selective inhibition by 3'-azido-2',3-dideoxythymidine-5'- triphosphate of reverse transcription in retrovirus A particles from the rat liver].

作者信息

Pyrinova G B, Kuz'minova E A, Salganik R I, Kraevskiĭ A A, Kukhanova M K

出版信息

Mol Biol (Mosk). 1988 Sep-Oct;22(5):1405-10.

PMID:2464740
Abstract

The data presented demonstrate that 3'-azido-2',3'-dideoxythymidine 5'-triphosphate [dTTP (3N3)] specifically inhibits reverse transcription of viral RNA in the endogenous retroviral A-type particles isolated from the rat liver. The inhibitory action of dTTP (3N3) is concerned the termination of DNA synthesis obviously due to the incorporation of this dideoxynucleotide into the 3'-end of the growing DNA chain.

摘要

所呈现的数据表明，3'-叠氮基-2',3'-双脱氧胸苷5'-三磷酸[dTTP(3N3)]能特异性抑制从大鼠肝脏分离出的内源性A型逆转录病毒颗粒中病毒RNA的逆转录。dTTP(3N3)的抑制作用显然与DNA合成的终止有关，这是由于这种双脱氧核苷酸掺入到正在生长的DNA链的3'-末端所致。

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