Pyrinova G B, Kuzminova E A, Salganik R I, Krayevsky A A, Kukhanova M M
Institute of Cytology and Genetics, Siberian Department of the USSR Academy of Sciences, Novosibirsk.
FEBS Lett. 1989 Apr 10;247(1):57-60. doi: 10.1016/0014-5793(89)81240-2.
The thymidine derivatives araAzT, dTTP(3'N3), TTP(3'NH2), and araTTP(3'N3), were studied as inhibitors of the reverse transcription taking place within endogenous retroviral A-type particles, where retroviral RNAs served as templates and primers, dTTP(3'N3) was shown to be the most efficient inhibitor of retroviral particle reverse transcription. Termination of DNA chain elongation is the basic mechanism of the inhibitory action of dTTP(3'N3). The compound has a very low inhibitory effect on mammalian DNA-dependent DNA polymerases alpha, beta and gamma.
对胸苷衍生物阿糖腺苷三磷酸（araAzT）、三磷酸脱氧胸苷（dTTP(3'N3)）、三磷酸胸苷（TTP(3'NH2)）和阿糖三磷酸胸苷（araTTP(3'N3)）作为内源性逆转录病毒A型颗粒内逆转录抑制剂进行了研究，其中逆转录病毒RNA作为模板和引物，结果表明dTTP(3'N3)是逆转录病毒颗粒逆转录最有效的抑制剂。DNA链延伸的终止是dTTP(3'N3)抑制作用的基本机制。该化合物对哺乳动物依赖DNA的DNA聚合酶α、β和γ的抑制作用非常低。
