van der Veen Erwin L, van Hulst Rob A, de Ru J Alexander
Department of Otorhinolaryngology, Central Military Hospital, Utrecht, The Netherlands Department of Otorhinolaryngology, University Medical Centre Utrecht, Utrecht, The Netherlands
Diving Medical Centre, Royal Netherlands Navy, Den Helder, The Netherlands Department of Hyperbaric Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
Otolaryngol Head Neck Surg. 2014 Jul;151(1):42-5. doi: 10.1177/0194599814526555. Epub 2014 Mar 19.
In this rapid systematic review, we studied the clinical question, What is the effect of hyperbaric oxygen therapy on hearing thresholds in patients who suffered a recent acute acoustic trauma? After screening for eligible titles and abstracts and extracting duplicates, 6 original research papers could be found. The general methodology of the studies was weak and the differences between these studies were too profound to pool the data, especially because of heterogeneity in adjuvant therapies, follow-up, and treatment protocol. The mean dB of hearing recovery in these studies ranged from 17 to 47 dB in the groups treated with hyperbaric oxygen versus 5 to 46 dB in the groups who did not receive hyperbaric oxygen therapy. We conclude that the effect of hyperbaric oxygen therapy on hearing thresholds in patients with hearing loss caused by a recent acute acoustic trauma remains unclear. A well-designed randomized controlled trial with enough power is advised to answer this clinical question.
在这项快速系统评价中,我们研究了以下临床问题:高压氧疗法对近期遭受急性声创伤患者的听力阈值有何影响?在筛选符合条件的标题和摘要并剔除重复项后,共找到6篇原创研究论文。这些研究的总体方法存在缺陷,且研究之间的差异过大,无法合并数据,尤其是由于辅助治疗、随访和治疗方案存在异质性。在接受高压氧治疗的组中,这些研究中听力恢复的平均分贝数在17至47分贝之间,而未接受高压氧治疗的组为5至46分贝。我们得出结论,高压氧疗法对近期急性声创伤所致听力损失患者的听力阈值的影响仍不明确。建议开展一项设计良好、有足够效力的随机对照试验来回答这一临床问题。