Yücel Aytaç, Ozturk Erdoğan, Aydoğan M Said, Durmuş Mahmut, Colak Cemil, Ersoy M Özcan
Department of Anesthesiology and Reanimation, Inonu University, Medical School, Malatya, Turkey.
Department of Anesthesiology and Reanimation, Bezmiâlem Vakif University, Medical School, Istanbul, Turkey.
Curr Ther Res Clin Exp. 2011 Aug;72(4):173-83. doi: 10.1016/j.curtheres.2011.06.004.
Pregabalin has a similar pharmacologic profile to that of its developmental predecessor gabapentin but has shown greater analgesic activity in rodent models of neuropathic pain.
The objective of the study was to compare the effects of 2 different doses of pregabalin and placebo on postoperative pain and morphine consumption.
Ninety patients who underwent abdominal hysterectomy were included in the study and randomly divided into 3 groups in a doubled-blinded manner. They were given 150 mg of pregabalin (group P300, n = 30), 300 mg of pregabalin (group P600, n = 30), or placebo capsules (group C, n = 30) 4 hours before the induction of anesthesia; they received a second dose of the drug 12 hours postoperatively. Morphine consumption, nausea, and vomiting, visual analogue scale-pain intensity (VAS-PI), sedation scores, and dissatisfaction scores were recorded in the postanesthesia care unit (PACU) and at 2, 4, 6, and 24 hours after operation.
Morphine consumption at 24 hours was 40.80 (3.42) mg, 33.79 (5.77) mg, and 46.97 (6.67) mg in groups P300, P600, and C, respectively (P < 0.001). VAS-PI scores at movement and at rest in the PACU and at 2, 4, and 6 hours decreased in group P600 (P < 0.01). In the PACU and at 2, 4, and 6 hours, the sedation scores were increased in group P600 compared with the scores in group C (P < 0.001, P < 0.001, P = 0.01, P = 0.006, respectively). Patient satisfaction was higher in group P600 than in group C for all time points (P < 0.001, P < 0.001, P < 0.001, P = 0.001, P < 0.001, respectively). There were no statistically significant differences between the groups for side effects such as nausea, vomiting, and dizziness (P = 0.58).
Pregabalin at a total dose of 600 mg, administered before operation and at 12 hours postoperatively after abdominal hysterectomy, reduced morphine consumption and pain intensity and increased patient satisfaction. No significant differences in side effects were observed between the study groups.
普瑞巴林的药理特性与其研发前身加巴喷丁相似，但在神经性疼痛的啮齿动物模型中显示出更强的镇痛活性。
本研究的目的是比较两种不同剂量的普瑞巴林和安慰剂对术后疼痛及吗啡用量的影响。
90例行腹部子宫切除术的患者纳入本研究，并以双盲方式随机分为3组。在麻醉诱导前4小时，分别给予150毫克普瑞巴林（P300组，n = 30）、300毫克普瑞巴林（P600组，n = 30）或安慰剂胶囊（C组，n = 30）；术后12小时给予第二剂药物。记录麻醉后监护病房（PACU）以及术后2、4、6和24小时的吗啡用量、恶心和呕吐情况、视觉模拟评分法疼痛强度（VAS-PI）、镇静评分和不满意评分。
P300组、P600组和C组术后24小时的吗啡用量分别为40.80（3.42）毫克、33.79（5.77）毫克和46.97（6.67）毫克（P < 0.001）。P600组在PACU以及术后2、4和6小时活动和静息时的VAS-PI评分降低（P < 0.01）。在PACU以及术后2、4和6小时，P600组的镇静评分高于C组（分别为P < 0.001、P < 0.001、P = 0.01、P = 0.006）。在所有时间点，P600组患者的满意度均高于C组（分别为P < 0.001、P < 0.001、P < 0.001、P = 0.001、P < 0.001）。在恶心、呕吐和头晕等副作用方面，各组之间无统计学显著差异（P = 0.58）。
腹部子宫切除术前及术后12小时给予总量600毫克的普瑞巴林，可减少吗啡用量和疼痛强度，并提高患者满意度。各研究组之间未观察到副作用有显著差异。
