Wu Jing, Zhang Dong-Sheng, Ji Mu-Huo, Zhang Zhuan, Yang Jian-Jun
Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, People's Republic of China.
Department of Anesthesiology, Yangzhou No.1 People's Hospital, Yangzhou, People's Republic of China.
Curr Ther Res Clin Exp. 2011 Dec;72(6):243-9. doi: 10.1016/j.curtheres.2011.10.001.
The aim of this study was to investigate the hemodynamic effects of epinephrine intravenous injection in healthy and hemorrhagic shock rats.
Forty Sprague-Dawley male rats weighing 250 to 300 g were randomly assigned to 4 groups: group NE, healthy rats receiving epinephrine 2 μg/kg; group NS, healthy rats receiving normal saline; group SE, hemorrhagic shock rats receiving epinephrine 2 μg/kg; and group SS, hemorrhagic shock rats receiving normal saline. Mean arterial blood pressure (MAP) and heart rate (HR) were recorded at the following time points: 0 seconds (baseline), 5 seconds, 15 seconds, 30 seconds, 1 minute, 2 minutes, 4 minutes, 6 minutes, 8 minutes, and 10 minutes (T0-9) after intravenous injection.
There were no significant differences in MAP and HR at baseline between groups NS and NE or between groups SS and SE. Compared with the figures for baseline, MAP had no significant change at all time points in groups NS and SS. MAP increased at T1-9 in group SE (P < 0.01). MAP increased at T1-3 and decreased at T5-6 in group NE (P < 0.01). There was no significant change in HR in all groups after epinephrine or normal saline injection.
Epinephrine 2 μg/kg intravenous injection elicited biphasic changes in blood pressure, which included an initial increase and a subsequent decrease in healthy rats and induced a remarkable increase in blood pressure in hemorrhagic shock rats.
本研究旨在探讨肾上腺素静脉注射对健康大鼠和失血性休克大鼠的血流动力学影响。
将40只体重250至300克的雄性Sprague-Dawley大鼠随机分为4组：NE组，健康大鼠接受2μg/kg肾上腺素；NS组，健康大鼠接受生理盐水；SE组，失血性休克大鼠接受2μg/kg肾上腺素；SS组，失血性休克大鼠接受生理盐水。在静脉注射后的以下时间点记录平均动脉血压（MAP）和心率（HR）：0秒（基线）、5秒、15秒、30秒、1分钟、2分钟、4分钟、6分钟、8分钟和10分钟（T0-9）。
NS组和NE组之间或SS组和SE组之间基线时的MAP和HR无显著差异。与基线数据相比，NS组和SS组在所有时间点的MAP均无显著变化。SE组在T1-9时MAP升高（P<0.01）。NE组在T1-3时MAP升高，在T5-6时MAP降低（P<0.01）。肾上腺素或生理盐水注射后所有组的HR均无显著变化。
静脉注射2μg/kg肾上腺素引起血压双相变化，包括健康大鼠最初升高随后降低，以及失血性休克大鼠血压显著升高。
