酸枣仁和栀子提取物协同改善小鼠模型的学习和记忆能力。
Semen Ziziphi Spinosae and Fructus Gardeniae extracts synergistically improve learning and memory of a mouse model.
作者信息
Li Baoli, Fu Zhaoying, Hu Rui, Chen Yahui, Zhang Zhengxiang
机构信息
Departments of Pharmacology, Medical College of Yan'an University, Yan'an 716000;
Molecular Biology, Medical College of Yan'an University, Yan'an 716000;
出版信息
Biomed Rep. 2013 Mar;1(2):247-250. doi: 10.3892/br.2012.38. Epub 2012 Nov 8.
Abstract
Semen Ziziphi Spinosae (SZS) and Fructus Gardeniae (FG) are two herbs commonly used in traditional Chinese medicine. Previous studies have suggested that Fructus Gardeniae as well as Semen Ziziphi Spinosae are able to regulate the function of the central nervous system. However, their effect on learning and memory has yet to be elucidated. In this study, we examined the effect of SZS and FG on the learning and memory of mice using the methods of step-through and -down passive avoidance tasks and Morris water maze tasks. The results showed that SZS and FG extracts have certain effects on improving the performance of the learning and memory-impaired mouse model. Of note, compound extracts of SZS and FG have a synergistic effect on the learning and memory of mice.
摘要
酸枣仁和栀子是两种常用的中药。先前的研究表明，栀子以及酸枣仁都能够调节中枢神经系统的功能。然而，它们对学习和记忆的影响尚未阐明。在本研究中，我们采用穿梭箱和跳台被动回避任务以及莫里斯水迷宫任务的方法，研究了酸枣仁和栀子对小鼠学习和记忆的影响。结果表明，酸枣仁和栀子提取物对改善学习和记忆受损小鼠模型的表现有一定作用。值得注意的是，酸枣仁和栀子的复方提取物对小鼠的学习和记忆有协同作用。
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本文引用的文献
1
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J Cell Biochem. 2012 Nov;113(11):3330-41. doi: 10.1002/jcb.24209.
2
Arachidonic acid randomizes endothelial cell motion and regulates adhesion and migration.花生四烯酸使内皮细胞运动随机化，并调节黏附和迁移。
PLoS One. 2011;6(9):e25196. doi: 10.1371/journal.pone.0025196. Epub 2011 Sep 23.
3
Comparative study of hypocholesterolemic and hypolipidemic effects of conjugated linolenic acid isomers against induced biochemical perturbations and aberration in erythrocyte membrane fluidity.共轭亚油酸异构体对诱导的生化紊乱和红细胞膜流动性异常的降胆固醇和降血脂作用的比较研究。
Eur J Nutr. 2012 Jun;51(4):483-95. doi: 10.1007/s00394-011-0233-0. Epub 2011 Aug 4.
4
Observation of insulin exocytosis by a pancreatic β cell line with total internal reflection fluorescence microscopy.利用全内反射荧光显微镜观察胰腺β细胞系的胰岛素胞吐作用。
Chin Med Sci J. 2011 Mar;26(1):60-3. doi: 10.1016/s1001-9294(11)60021-7.
5
Arachidonic acid pathway: A molecular target in human testicular cancer (Review).花生四烯酸途径：人类睾丸癌的分子靶点（综述）。
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6
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7
8
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9
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10
Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons.欧米伽-6和欧米伽-3脂肪酸预示着老年人周围神经功能的加速衰退。
Eur J Neurol. 2007 Jul;14(7):801-8. doi: 10.1111/j.1468-1331.2007.01860.x.
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