College of Food Science and Technology, Northwest University, Xi'an, China.
Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA.
J Food Biochem. 2022 Jul;46(7):e14153. doi: 10.1111/jfbc.14153. Epub 2022 Apr 11.
Ziziphi Spinosae Semen (the dried seeds of Ziziphus jujuba Mill. var. spinosa, Rhamnaceae) is a well-known traditional Chinese medicine (TCM) with high edible and pharmaceutical value. It contains abundant phytochemicals and possesses multiple biological activities. Phytochemicals include saponins, flavonoids, alkaloids, fatty acids, and others. Among them, saponins and flavonoids are considered to be the characteristic components of Ziziphi Spinosae Semen. Both crude extracts and isolated compounds exhibit excellent bioactivities, including sedative-hypnosis, anti-anxiety, antidepressant, anticancer, anti-inflammatory, anti-Alzheimer's disease (AD), and others. Its potential therapeutic effect on AD has received increasing attention in recent years. Updated reviews to summarize the current research progress and deficiencies are urgently needed. This review summarized its pharmacological activity, quality control, and application. In addition, the existing problems and future development directions are also discussed. PRACTICAL APPLICATIONS: Ziziphi Spinosae Semen is a vital traditional Chinese medicine that has a varied therapeutic effects. It is also added to food products due to its nontoxic properties. Reliable pharmacological studies have confirmed that it has multiple pharmacological activities. Particularly, its potential therapeutic effect on Alzheimer's disease (AD) has received significant attention, which makes Ziziphi Spinosae Semen an important potential candidate in the research of new drugs and health foods for the prevention of AD. This paper reviews the recent studies on Ziziphi Spinosae Semen in the treatment of AD. In addition, the quality control methods and practical applications are systematically summarized. It may provide essential guidance for the further utilization of Ziziphi Spinosae Semen in food and pharmaceutical industry.
酸枣仁（Ziziphus jujuba Mill. var. spinosa，鼠李科）是一种众所周知的中药，具有很高的食用和药用价值。它含有丰富的植物化学物质，具有多种生物活性。植物化学物质包括皂甙、黄酮类、生物碱、脂肪酸等。其中，皂甙和黄酮类被认为是酸枣仁的特征成分。酸枣仁的粗提取物和分离化合物都表现出出色的生物活性，包括镇静催眠、抗焦虑、抗抑郁、抗癌、抗炎、抗阿尔茨海默病（AD）等。近年来，其对 AD 的潜在治疗作用受到了越来越多的关注。急需更新的综述来总结当前的研究进展和不足之处。本文总结了其药理学活性、质量控制和应用。此外，还讨论了存在的问题和未来的发展方向。
酸枣仁是一种重要的中药，具有多种治疗作用。由于其无毒特性，它也被添加到食品产品中。可靠的药理学研究证实了它具有多种药理学活性。特别是，其对阿尔茨海默病（AD）的潜在治疗作用引起了广泛关注，这使得酸枣仁成为研究预防 AD 的新药和保健品的重要潜在候选药物。本文综述了近年来关于酸枣仁治疗 AD 的研究。此外，还系统地总结了其质量控制方法和实际应用。这可能为进一步在食品和制药行业中利用酸枣仁提供重要的指导。
